TY - JOUR AU - Palamarchuk, V.O. AU - Smolyar, V.A. AU - Tovkay, O.A. AU - Kuts, V.V. PY - 2022/03/27 Y2 - 2024/03/28 TI - Analysis of some prognostic factors significance for medullary thyroid cancer metastasis JF - INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) JA - Mìžnarodnij endokrinologìčnij žurnal VL - 18 IS - 1 SE - Original Researches DO - 10.22141/2224-0721.18.1.2022.1139 UR - https://iej.zaslavsky.com.ua/index.php/journal/article/view/1139 SP - 4-11 AB - <p><strong>Background.</strong> The urgency of the study is due to the need to find effective methods for the diagnosis and treatment of medullary thyroid cancer. Basal calcitonin is a biomarker that determines both the presence of this disease and the level of metastasis. Howe­ver, above-threshold calcitonin levels have a low prognostic value of the positive result. The study was aimed to analyze the importance of additional factors (besides calcitonin) in predicting the medullary thyroid cancer metastasis: age, sex, tumor focus, tumor volume (total volume). <strong>Materials and me­thods.</strong> A retrospective monocenter analysis was performed using the records of 194 patients treated for medullary thyroid cancer. The study involved 143 patients with primary forms of the di­sease. The required characteristics of the tumor were assessed in the postoperative period based on the pathomorphological exa­mination. <strong>Results.</strong> The association between age and metastasis was not found, but a moderate relationship between sex and metastasis has been shown. The ratio of the chances of metastases detected in male patients is estimated at 3 : 1. It is proved that in the presence of tumor multifocality, the likelihood of metastasis detection increa­ses. With an odds ratio of 2.368, the multifocal factor shows a weak but statistically significant strong association with the presence of metastases. Total tumor size is associated with metastasis. More than half (54.5 %) of cases are in the range of tumor sizes smaller than the selected cut-off threshold, with 16.7% metastasi­zing. On the other hand, the share of cases of exceeding the cut-off threshold (Cut-off = 1.9 cm; AUC = 0.703, Se = 0.745, Sp = 0.680) is 45.5 %, and metastasis is observed in 53.8 % of patients in this range. <strong>Conclusions.</strong> No association was found between age and metastasis. Male gender is a risk factor for metastasis. Multifocality is a risk factor for metastasis with a weak connection. The total size of the tumor is associated with metastasis with medium strength.</p> ER -