TY - JOUR AU - Pankiv, V.I. AU - Yuzvenko, T.Yu. AU - Koval, S.M. AU - Singh, K. AU - Pankiv, I.V. AU - Sehgal, Tarun AU - Lytvinova, O.M. PY - 2020/06/29 Y2 - 2024/03/29 TI - Correlation of vitamin D level with thyroid status and TSH antibody titers in patients with Graves’ disease JF - INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine) JA - Mìžnarodnij endokrinologìčnij žurnal VL - 16 IS - 4 SE - Original Researches DO - 10.22141/2224-0721.16.4.2020.208482 UR - https://iej.zaslavsky.com.ua/index.php/journal/article/view/102 SP - 305-309 AB - <div><p><strong><em>Background. </em></strong><em>Various studies have shown the association of vitamin D deficiency with autoimmune diseases. Studies have found that vitamin D levels in patients with autoimmune thyroid diseases including Graves’ disease were lower than that in patients with non-autoimmune thyroid diseases such as toxic nodular goiter. Some studies have reported no such relationship between vitamin D level and autoimmune thyroid di­seases. The purpose of the study:</em><strong> </strong><em>to compare serum vitamin D level in patients with Graves’ disease versus age and sex matched controls, to assess the correlation of vitamin D with thyroid status and thyrotropin receptor antibody titers. </em><strong><em>Materials and methods.</em></strong><em> 48 patients with Graves’ disease and 24 age and sex matched healthy individuals were recruited. Hormonal investigations that included serum thyroid stimulating hormone (TSH), free thyroxine (fT<sub>4</sub>), free triiodothyronine (fT<sub>3</sub>), as well as calcium, 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), thyroid stimulating hormone receptor antibody (TSH-Ab) were done for all subjects. </em><strong><em>Results.</em></strong><em> The patients with Graves’ disease had significantly lower 25(OH)D levels (16.3 ± 1.4 ng/ml) as compared to control subjects (22.8 ± 1.6 ng/ml) (p = 0.024). TSH levels and TSH-Ab titers differed significantly between vitamin D deficient Graves’ disease group (25(OH)D &lt; 20 ng/ml) and vitamin D non deficient Graves’ disease group (25(OH)D ≥ 20 ng/ml). Thyroid volume did not differ significantly between these groups. Serum vitamin D level correlated significantly with TSH and TSH-Ab titers in patients with Graves’ disease. </em><strong><em>Conclusions.</em></strong><em> Serum vitamin D levels are significantly lower in patients with Graves’ disease. Significant correlation between vitamin D and TSH and TSH-Ab titers was found in these patients.</em></p></div> ER -