@article{Yuzvenko_Tarasenko_Marchenko_2019, title={New opportunities for the use of alpha-lipoic acid: the role of enantiomers}, volume={15}, url={https://iej.zaslavsky.com.ua/index.php/journal/article/view/209}, DOI={10.22141/2224-0721.15.6.2019.185414}, abstractNote={The literature review considers the use of alpha-li­poic acid (ALA) in clinical practice. The positive effects of ALA as an antioxidant have been demonstrated for a wide range of diseases: diabetic neuropathy, atherosclerosis, hepatitis, cerebrovascular disorder, etc. The new data on the application of the R(+) enantiomer ALA has proved positive biological effects of ALA using. The only R(+) enantiomer ALA realizes all ALA positive features. The R(+) enantiomers of alpha-lipoic acid have the highest peak of plasma concentrations and AUC compared with racemic mixtures. It was showed that 300 mg of R(+) enantiomer of ALA is bioequivalent to 600 mg of racemic ALA.}, number={6}, journal={INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)}, author={Yuzvenko, T.Yu. and Tarasenko, S.A. and Marchenko, O.V.}, year={2019}, month={Oct.}, pages={507–514} }