@article{Luzanchuk_Kravchenko_Andrusishina_Golinko_2019, title={Study of macro- and microelement status in autoimmune thyroiditis among residents of districts of Kyiv region affected by the Chornobyl accident}, volume={15}, url={https://iej.zaslavsky.com.ua/index.php/journal/article/view/196}, DOI={10.22141/2224-0721.15.4.2019.174814}, abstractNote={<p class="a"><strong><em>Background.</em></strong> Autoimmune thyroiditis (AIT) is a combined, polygenic, organ­specific disease. The incidence rate of AIT has a tendency to increase throughout the world. There is an upward trend in morbidity in younger age groups. Circulating thyroid peroxidase antibodies are found in 10–15 % of apparently healthy euthyroid persons. The purpose of the study was to establish the macro­ and microelement status in patients with AIT among residents of districts of Kyiv region affected by the Chornobyl accident. <strong><em>Materials and methods.</em></strong> Sixty­one residents from the areas in Kyiv region affected by the Chornobyl accident were examined: 45 persons without thyroid pathology were included in the control group and 16 with AIT — in the experimental group. All patients with a thyroid dose of < 0.3 Gy — ≥ 1 Gy are participants of the cohort studies of Ukrainian­Belarusian­Ameri­can project. The study of micro­ and macroelements was performed by atomic emission spectroscopy with inductively coupled plasma (Dzherelo­2003) on Optima 2100 DV device (PerkinElmer, USA). <strong><em>Results.</em></strong> When studying thyroid status, the group of patients with AIT differed from the controls in terms of increased thyroid volume, high levels of thyroid pe­roxidase antibodies and thyroid­stimulating hormone. Urinary iodine excretion median in the studied groups was not significantly different: in the control group, it was 65.0 µg/l, in the experimental group — 80.6 µg/l, indicating the pre­sence of mild iodine deficiency. The examined patients with AIT had reduced (p < 0.01) magnesium level in the blood serum (the median value was 18.59 mg/l) compared to the control group. The assessment of the chances of correlation between AIT diagnosis and magnesium level below the median one (20.6 mg/l) in the total group of subjects was: odds ratio (OR) = 6.63 (95% confidence interval (CI) [1.73; 24.8]; p < 0.01). <strong><em>Conclusions.</em></strong> The existing diagnosis of AIT is reliably significant in patients with thyroid dose above median value (0.12 Gy)) in the total group of patients surveyed in the Kyiv region: OR = 4.1 (95% CI [1.2; 13.9]; p < 0.05). The odds ratio was highest with a combination of reduced magnesium content and increased thyroid radiation dose: OR = 25 (95% CI [3.16; 179.0]; p = 0.002).</p>}, number={4}, journal={INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)}, author={Luzanchuk, I.A. and Kravchenko, V.I. and Andrusishina, I.M. and Golinko, O.M.}, year={2019}, month={Jun.}, pages={290–297} }