@article{Povoroznyuk_Pankiv_Zaverukha_Solonenko_Musiienko_2020, title={Levels of bone turnover markers (N-terminal propeptide of type I procollagen and carboxy-terminal telopeptide of type I collagen) in Ukrainian population of different age and gender}, volume={16}, url={https://iej.zaslavsky.com.ua/index.php/journal/article/view/137}, DOI={10.22141/2224-0721.16.7.2020.219005}, abstractNote={<p><em><strong>Background.</strong> </em>The purpose was to determine the level of N-terminal of type I procollagen (PINP) and carboxy-terminal telopeptide of type I collagen (β-CTX) and their relationship in the serum of a healthy Ukrainian population of varying age and gender. <em><strong>Materials and methods.</strong></em> The study included 3,850 people aged 20–89 years (3,351 women (mean age 59.05 ± 13.89 years) and 499 men (49.17 ± 15.8 years). All participants were divided by age based on the gerontological age classification: young age 20–44 yrs, middle age 45–59 yrs, elderly 60–74 yrs, and old 75–89 yrs, and between 7 groups by decades: from 20 to 89. β-CTX and serum PINP concentrations were determined by electrochemiluminescence immunoassay ECLIA on a Cobas E411 analyzer. <em><strong>Results.</strong></em> We have detected a significant effect of age on serum β-CTX and PINP variability in men (F = 6.64, p < 0.001 and F = 4.93, p < 0.001) and women (F = 16.17, p < 0.001 and F = 10.46, p < 0.001, respectively). By Scheffe test detected a significantly higher level of β-CTX in the group of in women of 80–89 years compared with the groups of 20–29 years (p = 0.01), 30–39 years (p < 0.001), 40–49 years (p < 0.001), 50–59 years (0.52 ± 0.27, p = 0.002), 60–69 years (p = 0.001), and 70–79 years (p = 0.04). PINP rates in the group of 80–89 years were also significantly higher compared with the groups of 30–39 years (p < 0.001), 40–49 years (p < 0.001), 50–59 years (p = 0.009), 60–69 years (p = 0.002), and 70–79 years (p = 0.02). In men, a significant decrease in the concentration of β-CTX was revealed in the groups of: 30–39 years (p = 0.02), 40–49 years (p < 0.001), 50–59 years (p = 0.01), and 60–69 years (p = 0.001) compared with the group of 20–29 years. The level of PINP was significantly lower in the groups of 40–49 years (p < 0.001) and 50–59 years (p = 0.03) compared with the group of 20–29 years. According to the results of the study, the correlation coefficient between the concentration of PINP and β-CTX varies depending on age and sex. The highest correlation coefficients among both sexes were observed in the age groups of 40–49 years (women: r = 0.74; men: r = 0.64) and 50–59 (women: r = 0.74; men: r = 0.66); the lowest correlation coefficients were observed in women in the age group of 20–29 years (r = 0.63) and 70–79 (r = 0.65); in men (r = 0.53) aged 20–29 and 70–79 years. <em><strong>Conclusions.</strong> </em>It was detected a significant effect of age on serum variability of β-CTX and PINP in men and women. The highest dependence of β-CTX concentration on PINP by the coefficient of determination was observed in the groups of 40–49 and 50–59 years among both genders. The results can be used as a reference in almost healthy men and women, which in the future will be used for the research of bone metabolism in secondary osteoporosis and its complications.</p>}, number={7}, journal={INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine)}, author={Povoroznyuk, V.V. and Pankiv, I.V. and Zaverukha, N.V. and Solonenko, T.Yu. and Musiienko, A.S.}, year={2020}, month={Nov.}, pages={515–525} }