Efficacy of Early Combined Therapy with Metformin and Pioglitazone in Patients with Diabetes Mellitus Type 2
DOI:
https://doi.org/10.22141/2224-0721.0.2.42.2012.176862Keywords:
diabetes mellitus type 2, insulin resistance, metformin, pioglitazoneAbstract
Objective. To assess the efficacy of early treatment with metformin and pioglitazone in type 2 diabetes patients.
Material and methods. Twenty seven patients with decompensated type 2 diabetes mellitus treated with metformin were enrolled into the open-label study. The duration of type 2 diabetes mellitus was 3.6 ± 0.4 years. To achieve glycemic control pioglitazone was added to metformin. Before and after 16-week treatment we evaluated the parameters of carbohydrate and lipid metabolisms, degree of insulin resistance, function of beta-cells, body weight, structural and functional parameters of the heart and heart rhythm.
Results. At 24 weeks, the level of HbA1c decreased by 18.8 % (p < 0.05), fasting glycemia by 34.6 % (p < 0.001), postprandial glycemia by 37.8 % (p < 0.001), HOMA-IR by 57.9 % (p < 0.001). There was no deterioration of beta-cells dysfunction. Combined treatment improved lipid profile and parameters of cardiovascular system.
Conclusion. Early combined treatment with metformin and pioglitazone improved glycemic control and cardiovascular risk factors in type 2 diabetic patients.
Downloads
References
Ефимов А.С. Патогенез и лечение хронических осложнений сахарного диабета / А.С. Ефимов, Н.Д. Тронько, Л.К. Соколова // Вісник фармакології та фармації. — 2007. — № 11. — С. 27-34.
Маньковский Б.Н. Сердечно-сосудистые заболевания у больных сахарным диабетом: что важно знать кардиологу, эндокринологу и неврологу / Б.Н. Маньковский, О.Н. Барна // Ліки України. — 2010. — № 4 (140). — С. 24-28.
Сахарный диабет 2 типа: скрининг и факторы риска / Кравчун Н.А., Казаков А.В., Караченцев Ю.И. и др. — Харьков: Новое слово, 2010. — 256 с.
Шестакова М.В. Сахарный диабет и хроническая болезнь почек / М.В. Шестакова, И.И. Дедов. — М.: МИА, 2009. — 482 с.
Наказ МОЗ України від 22.05.2009 р. № 356 «Про затвердження протоколів надання медичної допомоги за спеціальністю «Ендокринологія».
Schernthaner G. Is the ADA/EASD algorithm for the management of type 2 diabetes (January 2009) based on evidence or opinion? A critical analysis / G. Schernthaner, A.H. Barnett, D.J. Betteridge et al. // Diabetologia. — 2010. — Vol. 53, № 7. — P. 1258-1269.
Type 2 diabetes in practice / Ed. A.J. Krentz, C.J. Bailey. — Royal Society of Medicine Press Ltd., 2007. — 190 p.
Downloads
Published
How to Cite
Issue
Section
License
Copyright (c) 2012 V.I. Pankiv
This work is licensed under a Creative Commons Attribution 4.0 International License.