The role of vitamin D deficiency in the origin of vasovagal syncope in childhood




vasovagal syncope, vitamin D, children


Background. Recent scientific findings suggest that vitamin D may play a mediated or, in some cases, a direct role in the pathogenesis of vasovagal syncope in children. The purpose of the research was to study the levels of vitamin D in the blood serum of children with vasovagal syncope. Mate­rials and methods. The main group consisted of 30 patients aged 8–17 years with at least one episode of vasovagal syncope during the last month. The control group included 24 apparently healthy children. 25(OH)D in the blood serum was determined by enzyme-linked immunosorbent assay using the Monobind test system (USA). Vitamin D status assessment was performed according to practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe: deficiency — < 20 ng/ml; suboptimal level (insufficiency) — 20–30 ng/ml; optimal concentration — 30–50 ng/ml; high le­vel — 50–100 ng/ml; dangerous concentration — > 100 ng/ml. Results. Children of the two groups were comparable in terms of demographic and clinical parameters. It helped eliminate the effect of gender, underweight and overweight, obesity or hypertension on 25(OH)D serum level. 25(OH)D in the vasovagal syncope group was 19.17 ± 1.33 ng/ml that was significantly lower compared to healthy children — 30.91 ± 1.20 ng/ml (p = 0.000001). Optimal concentration of vitamin D was recorded only in 6.7 % of patients with vasovagal syncope, whereas insufficiency and deficiency — in 33.3 and 60.0 %, respectively. Values of serum calcium, phosphorus, and alkaline phosphatase in children of both groups did not differ (p > 0.05). Conclusions. There is a significant decrease in serum level of 25(OH)D in 93.3 % of children with vasovagal syncope. The prevalence of vitamin D deficiency is 60.0 %, and suboptimal level of 25(OH)D was observed in 33.3 % of cases. Vitamin D deficiency and insufficiency are associated with maintaining traditional indicators of calcium-phosphorus homeostasis within the reference values.


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Płudowski P, Karczmarewicz E, Bayer M, et al. Practical guidelines for the supplementation of vitamin D and the treatment of deficits in Central Europe - recommended vitamin D intakes in the general population and groups at risk of vitamin D deficiency. Endokrynol Pol. 2013;64(4):319‐327. doi:10.5603/ep.2013.0012.

Butler IJ, Lankford JE, Hashmi SS, Numan MT. Biogenic amine metabolism in juvenile neurocardiogenic syncope with dysautonomia. Ann Clin Transl Neurol. 2014;1(4):251‐257. doi:10.1002/acn3.49.

Ghaznain M, Donnelly TM, Halpenny L. Tilt Table Test Outcome in the Diagnosis and Prevalence of Syncope in Patients with Vitamin D and Vitamin B12 Deficiency. Age and Ageing. 2017;46(Suppl 3):13-59. doi:10.1093/ageing/afx144.60.

Arici B, Maeder M, Schuetz P, Muelle B, Albrich WC. Potential role of biomarkers in the management of syncope. International Journal of Clinical Medicine. 2012;3(7A):744-750. doi:10.4236/ijcm.2012.37A131.

Wadhwania R. Is Vitamin D Deficiency Implicated in Autonomic Dysfunction? J Pediatr Neurosci. 2017;12(2):119‐123. doi:10.4103/jpn.JPN_1_17.

DeLuca GC, Kimball SM, Kolasinski J, Ramagopalan SV, Ebers GC. Review: the role of vitamin D in nervous system health and disease. Neuropathol Appl Neurobiol. 2013;39(5):458‐484. doi:10.1111/nan.12020.

Santillán GE, Vazquez G, Boland RL. Activation of a beta-adrenergic-sensitive signal transduction pathway by the secosteroid hormone 1,25-(OH)2-vitamin D3 in chick heart. J Mol Cell Cardiol. 1999;31(5):1095‐1104. doi:10.1006/jmcc.1999.0942.

Ashangari C, Suleman A. Vitamin D deficiency study in postural orthostatic tachycardia syndrome. Circulation: Cardiovascular Quality and Outcomes. 2015;8(Suppl 2):121.

Chaudhari SA, Sacerdote A, Bahtiyar G. 1-α hydroxylation defect in postural orthostatic tachycardia syndrome: remission with calcitriol supplementation. BMJ Case Rep. 2012;2012:bcr0220125730. doi:10.1136/bcr.02.2012.5730.

Matter M, El-Sherbiny E, Elmougy A, Abass M, Aldossary S, Ali WA. Myocardial function in Saudi adolescents with vitamin D deficiency: Tissue Doppler imaging study. J Saudi Heart Assoc. 2016;28(1):22‐30. doi:10.1016/j.jsha.2015.06.006.

Kovalchuk TA, Boyarchuk OR. Vitamin D status in patients with nontraumatic transient loss of consciousness (literature review). Bolʹ, sustavy, pozvonočnik. 2019;9(3):178-183. doi:10.22141/2224-1507.9.3.2019.178642.

Brignole M, Moya A, de Lange FJ, et al. 2018 ESC Guidelines for the diagnosis and management of syncope. Eur Heart J. 2018;39(21):1883‐1948. doi:10.1093/eurheartj/ehy037.

Pludowski P, Holick MF, Grant WB, et al. Vitamin D supplementation guidelines. J Steroid Biochem Mol Biol. 2018;175:125‐135. doi:10.1016/j.jsbmb.2017.01.021.

Kaminskyi OV, Pankiv VI, Pankiv IV, Afanasyev DE. Vitamin D content in population of radiologically contaminated areas in Chernivtsi oblast (pilot project). Probl Radiac Med Radiobiol. 2018;23:442‐451. doi:10.33145/2304-8336-2018-23-442-451.

Usalp S, Kemal H, Yüksek Ü, et al. Is there any link between vitamin D deficiency and vasovagal syncope? J Arrhythm. 2020;36(2):371‐376. Published 2020 Feb 10. doi:10.1002/joa3.12309.

Pankiv VI, Yuzvenko TYu, Pashkovska NV, Pankiv IV. Effect of vitamin D on insulin resistance and anthropometric parameters in patients with type 2 diabetes mellitus. Clinical Endocrinology and Endocrine Surgery. 2019;(1):53-58.

Sorokman TV, Popelyuk NA. Vitamin D as an independent predictor of obesity in adolescents. Mìžnarodnij endokrinologìčnij žurnal. 2018;14(5):449-453. doi:10.22141/2224-0721.14.5.2018.142679. (in Ukrainian).

Xu WR, Jin HF, Du JB. Vitamin D and Cardiovascular Risk in Children. Chin Med J (Engl). 2017;130(23):2857‐2862. doi:10.4103/0366-6999.215500.

Pilz S, Zittermann A, Trummer C, et al. Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect. 2019;8(2):R27‐R43. doi:10.1530/EC-18-0432.



How to Cite

Kovalchuk, T., & Boyarchuk, O. (2021). The role of vitamin D deficiency in the origin of vasovagal syncope in childhood. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 16(3), 231–236.



Original Researches