Treatment with Glucagon-Like Peptide-1 Analogues — a Breakthrough in Diabetes Mellitus Type 2 Therapy

Authors

  • V.L. Orlenko State Institution «Institute of Endocrinology and Metabolism named after V.P. Komissarenko of National Academy of Medical Sciences of Ukraine», Kyiv
  • K.P. Zak State Institution «Institute of Endocrinology and Metabolism named after V.P. Komissarenko of National Academy of Medical Sciences of Ukraine», Kyiv

DOI:

https://doi.org/10.22141/2224-0721.4.60.2014.76690

Keywords:

diabetes mellitus, glucagon, insulin, incretins, glucagon-like peptide-1

Abstract

The paper analyzes the data of modern scientific literature on the new class of drugs that restore the effect of glucagon-like peptide-1 (GLP-1). According to modern concepts, the pathophysio-logical mechanisms of therapeutic action of GLP-1 analogues in patients with diabetes mellitus (DM) type 2 primarily due to their bene-ficial effects on β-cell dysfunction, whose role in the pathogenesis of DM type 2 until recently been underestimated. The main targets of GLP-1 are pancreatic islets, where it glucose-dependently stimulates production and secretion of insulin and somatostatin secretion and inhibits glucagon secretion. Furthermore, GLP-1 inhibits β-cell destruction and stimulates their proliferation, increasing their number. The article presents information on the main multicenter studies on analogues of human GLP-1, analyzes hypoglycemic effectiveness of incretins and others of their positive effects.

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References

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Published

2022-02-18

How to Cite

Orlenko, V., & Zak, K. (2022). Treatment with Glucagon-Like Peptide-1 Analogues — a Breakthrough in Diabetes Mellitus Type 2 Therapy. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), (4.60), 112–117. https://doi.org/10.22141/2224-0721.4.60.2014.76690

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Section

Literature Review

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