Association between Polymorphism of Endothelial Nitric Oxide Synthase Gene (Glu298Asp) and Chronic Heart Failure in Patients with Ischemic Heart Disease and Obesity

Authors

  • O.I. Kadykova Kharkiv National Medical University, Kharkiv, Ukraine
  • P.P. Kravchun Kharkiv National Medical University, Kharkiv, Ukraine

DOI:

https://doi.org/10.22141/2224-0721.2.74.2016.70947

Keywords:

ischemic heart disease, obesity, polymorphisms of endothelial nitric oxide synthase gene, chronic heart failure.

Abstract

The article reviewed the links between polymorphism of endothelial nitric oxide synthase gene (Glu298Asp) and the development and progression of chronic heart failure in patients with ischemic heart disease and obesity. There has been a comprehensive survey of 222 patients with ischemic heart disease. Comparison group consisted of 115 patients with ischemic heart disease with normal body weight. The control group included 35 healthy individuals. G allele and genotype G/G polymorphism of the gene of endothelial nitric oxide synthase (Glu298Asp) was associated with the development of ischemic heart disease. The presence of allele G and G/G genotype polymorphism of the gene of endothelial nitric oxide synthase (Glu298Asp) in patients with ischemic heart disease with concomitant obesity has been associated with the development of chronic heart failure, while the A allele was associated with decreased risk of heart failure. Progression of chronic heart failure in patients with ischemic heart disease and obesity was associated with the G allele of polymorphism of endothelial nitric oxide synthase gene (Glu298Asp), and A allele has protective properties.

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References

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Published

2021-09-03

How to Cite

Kadykova, O., & Kravchun, P. (2021). Association between Polymorphism of Endothelial Nitric Oxide Synthase Gene (Glu298Asp) and Chronic Heart Failure in Patients with Ischemic Heart Disease and Obesity. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), (2.74), 106–110. https://doi.org/10.22141/2224-0721.2.74.2016.70947

Issue

Section

To practicing Endocrinologists

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