The Influence of Metformin on the Indices of Thyroid Panel, Carbohydrate and Lipid Metabolism in Patients with Diffuse Toxic Goiter and Insulin Resistance

Authors

  • O.Z. Lishchuk Lviv National Medical University named after Danylo Halytskyi, Department of Endocrinology, Lviv, Ukraine

DOI:

https://doi.org/10.22141/2224-0721.1.73.2016.71048

Keywords:

diffuse toxic goiter, insulin resistance, thyrozol, metformin.

Abstract

The goal of this investigation was to study the influence of metformin on the indices of thyroid hormones, carbohydrate and lipid metabolism in patients with diffuse toxic goiter and insulin resistance. The article presents the results of the study of 21 patients with diffuse toxic goiter. Treatment was conducted in two phases and each phase lasted for 3 months. During the first phase all patients received thyreostatic therapy with thyrozol, metformin was additionally prescribed in order to correct insulin resistance on the second phase. The obtained results are the evidence in favor of HOMA-IR index normalization by reducing glucose and fasting insulin, and slight increase in thyroid stimulating hormone and free thyroxine reduction within the referential standards against the background of combined treatment with thyrozol and metformin.

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Published

2021-09-03

How to Cite

Lishchuk, O. (2021). The Influence of Metformin on the Indices of Thyroid Panel, Carbohydrate and Lipid Metabolism in Patients with Diffuse Toxic Goiter and Insulin Resistance. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), (1.73), 21–24. https://doi.org/10.22141/2224-0721.1.73.2016.71048

Issue

Section

Clinical Thyroidology

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