Role of dyslipidemia in the development of nephropathy in patients with type 2 diabetes mellitus (literature review)
Keywords:type 2 diabetes mellitus, diabetic nephropathy, dyslipidemia, review
AbstractA literature review describes the role of dyslipidemia in the development of nephropathy in patients with type 2 diabetes mellitus. Chronic hyperlipidemia in diabetes is accompanied by damage and dysfunction of various organs and tissues due to a specific generalized change in the microvasculature or microangiopathy. Micro- and macroangiopathies lead to increased cardiovascular mortality in patients with type 2 diabetes mellitus. In patients with diabetes and chronic kidney disease, dyslipidemia can be exacerbated by hyperglycemia and insulin resistance. Control of dyslipidemia is an important therapeutic target, normalization of lipid metabolism and glycemic status reduces the risk of renal complications in type 2 diabetes mellitus.
Chaurand P, Norris JL, Cornett DS, Mobley JA, Caprioli RM. New developments in profiling and imaging of proteins from tissue sections by MALDI mass spectrometry. J Proteome Res. 2006 Nov;5(11):2889-900. doi: 10.1021/pr060346u.
Battisti WP, Palmisano J, Keane WE. Dyslipidemia in patients with type 2 diabetes. relationships between lipids, kidney disease and cardiovascular disease. Clin Chem Lab Med. 2003 Sep;41(9):1174-81. doi: 10.1515/CCLM.2003.181.
Zheng F, Zeng YJ, Plati AR, et al. Combined AGE inhibition and ACEi decreases the progression of established diabetic nephropathy in B6 db/db mice. Kidney Int. 2006 Aug;70(3):507-14. doi: 10.1038/sj.ki.5001578.
de Boer IH, Rue TC, Hall YN, Heagerty PJ, Weiss NS, Himmelfarb J. Temporal trends in the prevalence of diabetic kidney disease in the United States. JAMA. 2011 Jun 22;305(24):2532-9. doi: 10.1001/jama.2011.861.
Saran R, Robinson B, Abbott KC, et al. US Renal Data System 2018 Annual Data Report: epidemiology of kidney disease in the United States. Am J Kidney Dis. 2019 Mar;73(3S1):A7-A8. doi: 10.1053/j.ajkd.2019.01.001.
Sang VK, Kaduka L, Kamano J, Makworo D. Prevalence of Dyslipidaemia and The Associated Factors Among Type 2 Diabetes Patients in Turbo Sub-County. J Endocrinol Diab. 2017;4(5):1-9. doi: 10.15226/2374-6890/4/5/00190.
Angel PM, Spraggins JM, Baldwin HS, Caprioli R. Enhanced sensitivity for high spatial resolution lipid analysis by negative ion mode matrix assisted laser desorption ionization imaging mass spectrometry. Anal Chem. 2012 Feb 7;84(3):1557-64. doi: 10.1021/ac202383m.
De Koster J, Nelli RK, Strieder-Barboza C, de Souza J, Lock AL, Contreras GA. The contribution of hormone sensitive lipase to adipose tissue lipolysis and its regulation by insulin in periparturient dairy cows. Sci Rep. 2018 Sep 6;8(1):13378. doi: 10.1038/s41598-018-31582-4.
Hu ZJ, Ren LP, Wang C, Liu B, Song GY. Associations between apolipoprotein CIII concentrations and microalbuminuria in type 2 diabetes. Exp Ther Med. 2014 Sep;8(3):951-956. doi: 10.3892/etm.2014.1830.
Patel VI, Patel KP, Makadia MG, Shah AD, Chaudhari KS, Nilayangode HN. Levels of Apolipoprotein A1, B100 and Lipoprotein (a) in Controlled and Uncontrolled Diabetic Patients and in Non-Diabetic Healthy People. J Clin Diagn Res. 2017 Feb;11(2):BC01-BC05. doi: 10.7860/JCDR/2017/22741.9258.
Bouillet B, Gautier T, Blache D, et al. Glycation of apolipoprotein C1 impairs its CETP inhibitory property: pathophysiological relevance in patients with type 1 and type 2 diabetes. Diabetes Care. 2014 Apr;37(4):1148-56. doi: 10.2337/dc13-1467.
Feng X, Gao X, Yao Z, Xu Y. Low apoA-I is associated with insulin resistance in patients with impaired glucose tolerance: a cross-sectional study. Lipids Health Dis. 2017 Apr 4;16(1):69. doi: 10.1186/s12944-017-0446-1.
Brites F, Martin M, Guillas I, Kontush A. Antioxidative activity of high-density lipoprotein (HDL): Mechanistic insights into potential clinical benefit. BBA Clin. 2017 Aug 19;8:66-77. doi: 10.1016/j.bbacli.2017.07.002.
Kang MK, Park SH, Choi YJ, Shin D, Kang YH. Chrysin inhibits diabetic renal tubulointerstitialﬁbrosis through blocking epithelial to mesenchymal transition. J Mol Med (Berl). 2015 Jul;93(7):759-72. doi: 10.1007/s00109-015-1301-3.
Han DC, Isono M, Chen S, et al. Leptin stimulates type I collagen production in db/db mesangial cells: Glucose uptake and TGF-beta type II receptor expression. Kidney Int. 2001 Apr;59(4):1315-23. doi: 10.1046/j.1523-1755.2001.0590041315.x.
How to Cite
Copyright (c) 2019 S.I. Ismailov, S.U. Muminova
This work is licensed under a Creative Commons Attribution 4.0 International License.