Pathogenesis of diabetic retinopathy: a literature review


  • M.L. Kyryliuk MD, PhD, Professor, Head of the Department of neuroendocrinology and common endocrinology, Ukrainian Research and Practice Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, Ukraine.
  • V.A. Іshchenko Ophthalmologist, Department of Ophthalmology, Dnipropetrovsk State Medical Academy of the Ministry of Health of Ukraine, Dnipro



diabetic retinopathy, pathogenesis, review


The review presents data on the pathogenesis of diabetic retinopathy. The importance of increasing the activity of the polyol pathway of glucose metabolism, non-enzymatic glycation of proteins, activation of protein kinase C, carbonic anhydrase, hemodynamic changes and the activity of the renin-angiotensin system in the development of diabetes and its microvascular complications is indicated. Particular attention is paid to the role of oxidative stress, growth factors, as well as metabolic syndrome and obesity in the development and progression of diabetic retinopathy.


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How to Cite

Kyryliuk, M., & Іshchenko V. (2021). Pathogenesis of diabetic retinopathy: a literature review. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 15(7), 567–575.



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