Features of melatonin and serotonin secretion in young women with different body weight and their relationship with the development of insulin resistance
Keywords:obesity, overweight, melatonin, serotonin, leptin, insulin resistance
AbstractBackground. The relevance of the study is due to the significant prevalence of excess body weight of varying degrees among the young female population of Ukraine and the need for detail approaches to the early prevention of hormonal and metabolic complications of these pathological conditions in them. The purpose was to detail the peculiarities of the balance in the system of melatonin-serotonin-leptin sensitivity of peripheral tissues to insulin in women of reproductive age — representatives of the Ukrainian population with different body weight, including and taking into account the features of body composition. Materials and methods. We examined 130 women, whose average age was 28.64 ± 6.91 years, with exogenously constitutional excess body weight of varying degrees. Questionnaires assessed the presence of sleep disorders. The body mass index and waist circumference were determined. The method of bioimpedance analysis helped evaluate the composition of the body (fatty, relative fatty, lean, active body cell mass), enzyme-linked immunosorbent assay — the level of insulin- and leptinemia. Homeostasis model assessment was calculated. Melatonin secretion was evaluated by the urine content of its metabolite 6-sulfate-oxymelatonin (6-SOMT) according to the Druex method modified by V. Zubkov; serotonin — using fluorimetric method of V.I. Kulynskyi and L. Kostiukovska. Results. In young women — representatives of the Ukrainian population, the degree of adipose tissue accumulation in the body negatively correlates with the level of serotoninemia, night and average daily urine excretion of 6-SOMT; positively — with the level of the daily fraction of 6-SOMT urine excretion. A decrease in the average daily excretion of 6-SOMT and the serotonin content in the circulation are associated with an increase in the homeostasis model assessment and the level of leptinemia. The development of abdominal obesity in young women — representatives of the Ukrainian population is characterized by a decrease in serotonin level in the circulation, a reduction in the urine excretion of nighttime 6-SOMT fraction, while the daily increase is observed. With a subsequent increase in waist circumference, the above changes are exacerbated. Conclusions. Reduced serotonin levels in the circulation, decreased nocturnal melatonin excretion fraction with a simultaneous increase of a daytime one is a significant difference in obese patients compared to overweight women.
Handbook of performance indicators of the endocrinological care of Ukraine for 2014. Endocrinology. 2015;20(Suppl 1):1-38. (in Ukrainian).
WHO. Obesity and overweight. 2016. Available from: https://www.who.int/news-room/fact-sheets/detail/obesity-and-overweight.
Brown A, Guess N, Dornhorst A, Taheri S, Frost G. Insulin-associated weight gain in obese type 2 diabetes mellitus patients: What can be done? Diabetes Obes Metab. 2017 Dec;19(12):1655-1668. doi: 10.1111/dom.13009.
Crane JD, Palanivel R, Mottillo EP, et al. Inhibiting peripheral serotonin synthesis reduces obesity and metabolic dysfunction by promoting brown adipose tissue thermogenesis. Nat Med. 2015 Feb;21(2):166-72. doi: 10.1038/nm.3766.
McCuen-Wurst C, Ruggieri M, Allison KC. Disordered eating and obesity: associations between binge-eating disorder, night-eating syndrome, and weight-related comorbidities. Ann N Y Acad Sci. 2018 Jan;1411(1):96-105. doi: 10.1111/nyas.13467.
World Medical Association Declaration of Helsinki. Ethical Principles for Medical Research Involving Human Subjects. WMA, 2004. 32 p.
International Diabetes Federation. The IDF consensus worldwide definition of the metabolic syndrome, 2005. Available from: https://www.idf.org/e-library/consensus-statements/60-idfconsensus-worldwide-definitionof-the-metabolic-syndrome.html.
De Lorenzo A, Andreoli A, Matthie J, Withers P. Predicting body cell mass with bioimpedance by using theoretical methods: a technological review. J Appl Physiol (1985). 1997 May;82(5):1542-58. doi: 10.1152/jappl.19220.127.116.112.
Gudivaka R, Schoeller DA, Kushner RF, Bolt MJ. Single- and multifrequency models for bioelectrical impedance of body water compartments. J Appl Physiol (1985). 1999 Sep;87(3):1087-96. doi: 10.1152/jappl.1918.104.22.1687.
Taheri S, Lin L, Austin D, Young T, Mignot E. Short sleep duration is associated with reduced leptin, elevated ghrelin, and increased body mass index. PLoS Med. 2004 Dec;1(3):e62. doi: 10.1371/journal.pmed.0010062.
Malazonia A, Zerekidze T, Giorgadze E, Chkheidze N, Asatiani K. Melatonin Level Variations with Different Behavioural Risk Factors in Obese Female Patients. Open Access Maced J Med Sci. 2017 Aug 12;5(5):613-617. doi: 10.3889/oamjms.2017.063.
How to Cite
Copyright (c) 2019 K.V. Misyura, K.G. Manska
This work is licensed under a Creative Commons Attribution 4.0 International License.