Features of melatonin and serotonin secretion in young women with different body weight and their relationship with the development of insulin resistance


  • K.V. Misyura MD, PhD, Senior Research Fellow, scientific Secretary of the State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, Alchevskyh st., 10, Kharkiv, 61002, Ukraine http://orcid.org/0000-0002-0258-9109
  • K.G. Manska State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, Alchevskyh st., 10, Kharkiv, 61002, Ukraine




obesity, overweight, melatonin, serotonin, leptin, insulin resistance


Background. The relevance of the study is due to the significant prevalence of excess body weight of varying degrees among the young female population of Ukraine and the need for detail approaches to the early prevention of hormonal and metabolic complications of these pathological conditions in them. The purpose was to detail the peculiarities of the balance in the system of melatonin-serotonin-leptin sensitivity of peripheral tissues to insulin in women of reproductive age — representatives of the Ukrainian population with different body weight, including and taking into account the features of body composition. Materials and methods. We examined 130 women, whose average age was 28.64 ± 6.91 years, with exo­genously constitutional excess body weight of varying degrees. Questionnaires assessed the presence of sleep disorders. The body mass index and waist circumference were determined. The method of bioimpedance analysis helped evaluate the composition of the body (fatty, relative fatty, lean, active body cell mass), enzyme-linked immunosorbent assay — the level of insulin- and leptinemia. Homeostasis model assessment was calculated. Melatonin secretion was evaluated by the urine content of its metabolite 6-sulfate-oxymelatonin (6-SOMT) according to the Druex method modified by V. Zubkov; serotonin — using fluorimetric method of V.I. Kulynskyi and L. Kostiukovska. Results. In young women — representatives of the Ukrainian population, the degree of adipose tissue accumulation in the body negatively correlates with the level of serotoninemia, night and average daily urine excretion of 6-SOMT; positively — with the level of the daily fraction of 6-SOMT urine excretion. A decrease in the average daily excretion of 6-SOMT and the serotonin content in the circulation are associated with an increase in the homeostasis model assessment and the level of leptinemia. The development of abdominal obesity in young women — representatives of the Ukrainian population is characterized by a decrease in serotonin level in the circulation, a reduction in the urine excretion of nighttime 6-SOMT fraction, while the daily increase is observed. With a subsequent increase in waist circumference, the above changes are exacerbated. Conclusions. Reduced serotonin levels in the circulation, decreased nocturnal melatonin excretion fraction with a simultaneous increase of a daytime one is a significant difference in obese patients compared to overweight women.


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How to Cite

Misyura, K., & Manska, K. (2021). Features of melatonin and serotonin secretion in young women with different body weight and their relationship with the development of insulin resistance. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 15(6), 443–452. https://doi.org/10.22141/2224-0721.15.6.2019.185406



Original Researches