The combination of obesity with various infections as an interdisciplinary problem of modern clinical medicine

Authors

  • I.V. Pankiv MD, PhD, Associate Professor at the Department of clinical immunology, allergology and endocrinology, Bukovinian State Medical University, Chernivtsi, Ukraine http://orcid.org/0000-0001-5576-636X

DOI:

https://doi.org/10.22141/2224-0721.15.6.2019.185413

Keywords:

obesity, infection, adipokines, Styfimol, review

Abstract

A review of the literature is devoted to the problem of obesity and infection comorbidity. The increased tendency of patients with obesity towards respiratory, viral, postoperative and other infections is considered. One of the pathogenetic mechanisms for the development of infections in obese patients is the dysfunction of cellular and humoral immunity, induced by the production of various cytokines by adipose tissue, which have an immunomodulatory effect. Further studies are needed in the field of epidemiology, mechanisms for the development and course of infections in obese patients, and the development of tactics to assist this category of patients. The results of the positive effect of the domestic drug Styfimol on weight loss due to abdominal adipose tissue in individuals with overweight and obesity are presented.

Downloads

Download data is not yet available.

References

Hainer V, Zamrazilova H, Kunešova M, et al. Obesity and infection: reciprocal causality. Physiol Res. 2015;64 Suppl 2:S105-19.

Huttunen R, Syrjänen J. Obesity and the risk and outcome of infection. Int J Obes (Lond). 2013;37(3):333-40. doi: 10.1038/ijo.2012.62.

Atkinson RL. Viruses as an etiology of obesity. Mayo Clin Proc. 2007;82(10):1192-8. doi: 10.4065/82.10.1192.

Dhurandhar NV, Whigham LD, Abbott DH, et al. Human Adenovirus Ad-36 Promotes Weight Gain in Male Rhesus and Marmoset Monkeys. J Nutr. 2002;132(10):3155-3160. doi: 10.1093/jn/131.10.3155.

Ashburn DD, DeAntonio A, Reed MJ. Pulmonary System and Obesity. Crit Care Clin. 2010;26(4):597-602. doi: 10.1016/j.ccc.2010.06.008.

Malhotra A, Hillman D. Obesity and the lung: 3. Obesity, respiration and intensive care. Thorax. 2008;63(10):925-31. doi: 10.1136/thx.2007.086835.

Morris AE, Stapleton RD, Rubenfeld GD, Hudson LD, Caldwell E, Steinberg KP. The association between body mass index and clinical outcomes in acute lung injury. Chest. 2007 Feb;131(2):342-8. doi: 10.1378/chest.06-1709.

Jedrychowski W, Maugeri U, Flak E, Mroz E, Bianchi I. Predisposition to acute respiratory infections among overweight preadolescent children. Public Health. 1998;112(3):189-195. doi: 10.1038/sj.ph.1900438.

Baik I, Curhan GC, Rimm EB, Bendich A, Willett WC, Fawzi WW. A Prospective Study of Age and Lifestyle Factors in Relation to Community-Acquired Pneumonia in US Men and Women. Arch Intern Med. 2000;160(20):3082-3088. doi: 10.1001/archinte.160.20.3082.

Phung DT, Wang Z, Rutherford S, Huang C, Chu C. Body mass index and risk of pneumonia: a systematic review and meta-analysis. Obes Rev. 2013;14(10):839-857. doi: 10.1111/obr.12055.

Semins MJ, Shore AD, Makary MA, Weiner J, Matlaga BR. The Impact of Obesity on Urinary Tract Infection Risk. Urology. 2012;79(2):266-269. doi: 10.1016/j.urology.2011.09.040.

Ribera MC, Pascual R, Orozco D, Pérez Barba C, Pedrera V, Gil V. Incidence and risk factors associated with urinary tract infection in diabetic patients with and without asymptomatic bacteriuria. Eur J Clin Microbiol Infect Dis. 2006;25(6):389-393. doi: 10.1007/s10096-006-0148-5.

Wurzinger B, Dunser MW, Wohlmuth C, et al. The association between body-mass index and patient outcome in septic shock: a retrospective cohort study. Wien Klin Wochenschr. 2010; 122(1-2):31-36. doi: 10.1007/s00508-009-1241-4.

Basu JK, Jeketera CM, Basu D. Obesity and its outcomes among pregnant South African women. Int J Gynecol Obstet. 2010;110(2):101-104. doi: 10.1016/j.ijgo.2010.02.020.

Usha Kiran TS, Hemmadi S, Bethel J, Evans J. Outcome of pregnancy in a woman with an increased body mass index. BJOG. 2005;112(6):768-772. doi: 10.1111/j.1471-0528.2004.00546.x.

Bamgbade OA, Rutter TW, Nafiu OO, Dorje P. Postoperative Complications in Obese and Nonobese Patients. World J Surg. 2007;31(3):556-560. doi: 10.1007/s00268-006-0305-0.

Morgan OW, Bramley A, Fowlkes A, et al. Morbid Obesity as a Risk Factor for Hospitalization and Death Due to 2009 Pandemic Influenza A(H1N1) Disease. PLoS One. 2010;5(3):e9694. doi: 10.1371/journal.pone.0009694.

Neidich SD, Green WD, Rebeles J, et al. Increased risk of influenza among vaccinated adults who are obese. Int J Obes. 2017;41(9):1324-1330. doi: 10.1038/ijo.2017.131.

Louie JK, Acosta M, Samuel MC, et al. A Novel Risk Factor for a Novel Virus: Obesity and 2009 Pandemic Influenza A (H1N1). Clin Infect Dis. 2011;52(3):301-312. doi: 10.1093/cid/ciq152.

Almond MH, Edwards MR, Barclay WS, Johnston SL. Obesity and susceptibility to severe outcomes following respiratory viral infection. Thorax. 2013;68(7):684-686. doi: 10.1136/thoraxjnl-2012-203009.

Garcia MN, Philpott DC, Murray KO, et al. Clinical predictors of disease severity during the 2009–2010 A(HIN1) influenza virus pandemic in a paediatric population. Epidemiol Infect. 2015;143(14):2939-2949. doi: 10.1017/S0950268815000114.

Kwong JC, Campitelli MA, Rosella LC. Obesity and Respiratory Hospitalizations During Influenza Seasons in Ontario, Canada: A Cohort Study. Clin Infect Dis. 2011;53(5):413-421. doi: 10.1093/cid/cir442.

Weber DJ. Obesity as a predictor of poor antibody response to hepatitis B plasma vaccine. J Am Med Assoc. 1985;254(22):3187-3189. doi: 10.1001/jama.1985.03360220053027.

Weber DJ, Rutala WA, Samsa GP, Bradshaw SE, Lemon SM. Impaired immunogenicity of hepatitis B vaccine in obese persons. N Engl J Med. 1986;314(21):1393-1393. doi: 10.1056/NEJM198605223142119.

Young MD, Gooch WM, Zuckerman AJ, Du W, Dickson B, Maddrey WC. Comparison of a triple antigen and a single antigen recombinant vaccine for adult hepatitis B vaccination. J Med Virol. 2001;64(3):290-298. doi: 10.1002/jmv.1049.

Anaya DA, Dellinger EP. The Obese Surgical Patient: A Susceptible Host for Infection. Surg Infect (Larchmt). 2006;7(5):473-480. doi: 10.1089/sur.2006.7.473.

Falagas ME, Kompoti M. Obesity and infection. Lancet Infect Dis. 2006;6(7):438-446. doi: 10.1016/S1473-3099(06)70523-0.

Dorner TE, Schwarz F, Kranz A, Freidl W, Rieder AGisinger C. Body mass index and the risk of infections in institutionalised geriatric patients. Br J Nutr. 2010;103(12):1830-1835. doi: 10.1017/S0007114510000152.

Swenne C, Lindholm C, Borowiec J, Carlsson M. Surgical-site infections within 60 days of coronary artery by-pass graft surgery. J Hosp. Infect. 2004;57(1):14-24. doi: 10.1016/j.jhin.2004.02.005.

Crabtree TD, Codd JE, Fraser VJ, Bailey MS, Olsen MA, Damiano RJ Jr. Multivariate analysis of risk factors for deep and superficial sternal infection after coronary artery bypass grafting at a tertiary care medical center. Semin Thorac Cardiovasc Surg. 2004;16(1):53-61. doi: 10.1053/j.semtcvs.2004.01.009.

Waisbren E, Rosen H, Bader AM, Lipsitz SR, Rogers SO Jr, Eriksson E. Percent Body Fat and Prediction of Surgical Site Infection. J Am Coll Surg. 2010;210(4):381-389. doi: 10.1016/j.jamcollsurg.2010.01.004.

Winfield RD, Reese S, Bochicchio K, Mazuski JE, Bochicchio GV. Obesity and the Risk for Surgical Site Infection in Abdominal Surgery. Am Surg. 2016;82(4):331-336.

Bercault N, Boulain T, Kuteifan K, Wolf M, Runge I, Fleury JC. Obesity-related excess mortality rate in an adult intensive care unit: A risk-adjusted matched cohort study. Crit Care Med. 2004;32(4):998-1003. doi: 10.1097/01.CCM.0000119422.93413.08.

Yaegashi M, Jean R, Zuriqat M, Noack S, Homel P. Outcome of Morbid Obesity in the Intensive Care Unit. J Intensive Care Med. 2005;20(3):147-154. doi: 10.1177/0885066605275314.

Mast BA. Safety and efficacy of outpatient full abdominoplasty. Ann Plast Surg. 2005;54(3):256-259. doi: 10.1097/01.sap.0000153161.22512.ab.

Andrews TR, Perdikis G, Shack RB. Herpes Zoster as a Rare Complication of Liposuction. Plast Reconstr Surg. 2004;113(6):1838-1840. doi: 10.1097/01.prs.0000117663.06099.a0.

Kakarla VR, Nandipati K, Lalla M, Castro A, Merola S. Are laparoscopic bariatric procedures safe in superobese (BMI ≥50 kg/m2) patients? An NSQIP data analysis. Surg Obes Relat Dis. 2011;7(4):452-458. doi: 10.1016/j.soard.2010.10.009.

Chopra T, Marchaim D, Lynch Y, et al. Epidemiology and outcomes associated with surgical site infection following bariatric surgery. Am J Infect Control. 2012;40(9):815-819. doi: 10.1016/j.ajic.2011.10.015.

Williams MD, Champion JK. Experience with routine intraabdominal cultures during laparoscopic gastric bypass with implications for antibiotic prophylaxis. Surg Endosc. 2004;18(5):755-756. doi: 10.1007/s00464-003-8198-6.

Friedman JM. A War on Obesity, Not the Obese. Science. 2003;299(5608):856-858. doi: 10.1126/science.1079856.

Gualillo O, Gonzalez-Juanatey JR, Lago F. The Emerging Role of Adipokines as Mediators of Cardiovascular Function: Physiologic and Clinical Perspectives. Trends Cardiovasc Med. 2007;17(8):275-283. doi: 10.1016/j.tcm.2007.09.005.

Halberg N, Wernstedt-Asterholm I, Scherer PE. The Adipocyte as an Endocrine Cell. Endocrinol Metab Clin North Am. 2008;37(3):753-768. doi: 10.1016/j.ecl.2008.07.002.

Bluher M. Adipose Tissue Dysfunction in Obesity. Exp Clin Endocrinol Diabetes. 2009;117(06):241-250. doi: 10.1055/s-0029-1192044.

Nieman DC, Henson DA, Nehlsen-Cannarella SL, et al. Influence of Obesity on Immune Function. J Am Diet Assoc. 1999;99(3):294-299. doi: 10.1016/S0002-8223(99)00077-2.

Tanaka S-I, Isoda F, Ishihara Y, Kimura M, Yamakawa T. T lymphopaenia in relation to body mass index and TNF-alpha in human obesity: adequate weight reduction can be corrective. Clin Endocrinol (Oxf). 2001;54(3):347-354. doi: 10.1046/j.1365-2265.2001.1139/cn2155.x.

Lynch LA, O’Connell JM, Kwasnik AK, Cawood TJ, O'Farrelly C, O'Shea DB. Are Natural Killer Cells Protecting the Metabolically Healthy Obese Patient? Obesity. 2009;17(3):601-605. doi: 10.1038/oby.2008.565.

Marti A, Marcos A, Martinez JA. Obesity and immune function relationships. Obes Rev. 2001;2(2):131-140. doi: 10.1046/j.1467-789x.2001.00025.x.

Hur SJ, Kim DH, Chun SC, Lee SK. Effect of adenovirus and influenza virus infection on obesity. Life Sci. 2013;93(16):531-535. doi: 10.1016/j.lfs.2013.08.016.

Myers MG, Cowley MA, Munzberg H. Mechanisms of Leptin Action and Leptin Resistance. Annu Rev Physiol. 2008;70(1):537-556. doi: 10.1146/annurev.physiol.70.113006.100707.

Morrison CD. Leptin resistance and the response to positive energy balance. Physiol Behav. 2008;94(5):660-663. doi: 10.1016/j.physbeh.2008.04.009.

Karlsson EA, Beck MA. The burden of obesity on infectious disease. Exp Biol Med. 2010;235(12):1412-1424. doi: 10.1258/ebm.2010.010227.

Zarkesh-Esfahani H, Pockley AG, Wu Z, Hellewell PG, Weetman AP, Ross RJ. Leptin Indirectly Activates Human Neutrophils via Induction of TNF-α. J Immunol. 2004;172(3):1809-1814. doi: 10.4049/jimmunol.172.3.1809.

Fantuzzi G, Faggioni R. Leptin in the regulation of immunity, inflammation, and hematopoiesis. J Leukoc Biol. 2000;68(4):437-446.

Ozata M, Ozdemir IC, Licinio J. Human Leptin Deficiency Caused by a Missense Mutation: Multiple Endocrine Defects, Decreased Sympathetic Tone, and Immune System Dysfunction Indicate New Targets for Leptin Action, Greater Central than Peripheral Resistance to the Effects of Leptin, and Spontaneous Correction of Leptin-Mediated Defects. J Clin Endocrinol Metab. 1999;84(10):3686-3695. doi: 10.1210/jcem.84.10.5999.

La Cava A, Alviggi C, Matarese G. Unraveling the multiple roles of leptin in inflammation and autoimmunity. J Mol Med. 2004;82(1):4-11. doi: 10.1007/s00109-003-0492-1.

Chatterjee A, Bagchi D, Stohs SJ. Physico-chemical properties of a novel hydroxусіtric acid extract and its effect on body weight, selected organ weights, hepatic lipid peroxidation and DNA fragmentation, hematology and clinical chemistry, and histopathological changes over a period of 90 days. Molec. Cell Biochem. 2004;260:171-186.

Ohia SE, Opere CA, LeDay, Bagchi M, Bagchi D, Stohs SJ. Safety and mechanismof appetite suppression by a novel hydroxycitric acid extract (HCA-SX). Molecular and Cellular Biochemistry. 2002;238:89-103 doi: 10.1023/a:1019911205672.

Hayamizu K, Ishii Y, Kaneko I, et al. Effects of Garcinia cambogia (hydroxycitric acid) on visceral fat accumulation: a double-blind, randomized, placebo-controlled trial. Curr Ther Res Clin Exp. 2003 Sep;64(8):551-67. doi: 10.1016/j.curtheres.2003.08.006.

Chinevere TD, Sawyer RD, Creer AR, Conlee RK, Parcell AC. Effects of L-tyrosine and carbohydrate ingestion on endurance exercise performance. J Appl Physiol (1985). 2002 Nov;93(5):1590-1597. doi: 10.1152/japplphysiol.00625.2001.

Broadhurst CL, Domenico P. Clinical studies on chromium picolinate supplementation in diabetes mellitus. Diabetes Technol. Ther. 2006;8(6):677-687. doi: 10.1089/dia.2006.8.677.

Lee MS, Lee HJ, Lee HS, Kim Y. L-carnitine stimulates lipolysis via induction of the lipolytic gene expression and suppression of the adipogenic gene expression in 3T3-L1 adipocytes. J. Med Food. 2006;9:468-473. doi: 10.1089/jmf.2006.9.468.

Zuiev KO. Features of bariatric exposure to Stifimol in patients with type 2 diabetes with obesity and hypertension. Mìžnarodnij endokrinologìčnij žurnal. 2017;8(13):596-603. doi: 10.22141/2224-0721.13.8.2017.119277. (in Ukrainian).

Published

2021-09-01

How to Cite

Pankiv, I. (2021). The combination of obesity with various infections as an interdisciplinary problem of modern clinical medicine. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 15(6), 501–506. https://doi.org/10.22141/2224-0721.15.6.2019.185413

Issue

Section

Literature Review

Most read articles by the same author(s)

1 2 3 4 > >>