New opportunities for the use of alpha-lipoic acid: the role of enantiomers

Authors

  • T.Yu. Yuzvenko MD, PhD, Deputy Director, Ukrainian Research and Practice Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, Ukraine http://orcid.org/0000-0003-4229-2075
  • S.A. Tarasenko PhD, Anesthesiologist, Department of prophylaxis and treatment of diabetes, Ukrainian Research and Practice Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, Ukraine http://orcid.org/0000-0001-9970-4574
  • O.V. Marchenko Endocrinologist, Department of prophylaxis and treatment of diabetes, Ukrainian Research and Practice Center of Endocrine Surgery, Transplantation of Endocrine Organs and Tissues of the Ministry of Health of Ukraine, Kyiv, Ukraine http://orcid.org/0000-0002-8040-9687

DOI:

https://doi.org/10.22141/2224-0721.15.6.2019.185414

Keywords:

alpha-lipoic acid, enantiomers, review

Abstract

The literature review considers the use of alpha-li­poic acid (ALA) in clinical practice. The positive effects of ALA as an antioxidant have been demonstrated for a wide range of diseases: diabetic neuropathy, atherosclerosis, hepatitis, cerebrovascular disorder, etc. The new data on the application of the R(+) enantiomer ALA has proved positive biological effects of ALA using. The only R(+) enantiomer ALA realizes all ALA positive features. The R(+) enantiomers of alpha-lipoic acid have the highest peak of plasma concentrations and AUC compared with racemic mixtures. It was showed that 300 mg of R(+) enantiomer of ALA is bioequivalent to 600 mg of racemic ALA.

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References

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Published

2021-09-01

How to Cite

Yuzvenko, T., Tarasenko, S., & Marchenko, O. (2021). New opportunities for the use of alpha-lipoic acid: the role of enantiomers. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 15(6), 507–514. https://doi.org/10.22141/2224-0721.15.6.2019.185414

Issue

Vol. 15 No. 6 (2019)

Section

Literature Review

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Copyright (c) 2019 T.Yu. Yuzvenko, S.A. Tarasenko, O.V. Marchenko

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This work is licensed under a Creative Commons Attribution 4.0 International License.

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