Is there any relationship between Hashimoto’s thyroiditis and urinary iodine level?


  • A. Turgut Ege University Medical School, Department of İnternal Medicine, Bornova, Izmir, Turkey
  • M. Erdogan Ege University Medical School, Department of Endocrinology and Metabolic Diseases, Bornova, Izmir, Turkey
  • B.S. Yurekli Ege University Medical School, Department of Endocrinology and Metabolic Diseases, Bornova, Izmir, Turkey
  • E. Sezer Ege University Medical School, Department of Medical Biochemistry, Bornova, Izmir, Turkey
  • I.Y. Simsir Ege University Medical School, Department of Endocrinology and Metabolic Diseases, Bornova, Izmir, Turkey
  • H. Rouhrazi Ege University Medical School, Department of Medical Biochemistry, Bornova, Izmir, Turkey
  • N. Turgan Ege University Medical School, Department of Medical Biochemistry, Bornova, Izmir, Turkey; Medical Biochemistry Department of the Medical Faculty of Near East University in Nicosia, Cyprus



urinary iodine, autoimmune, Hashimoto’s thyroiditis


Background. Hashimoto’s thyroiditis (HT) is an autoimmune disease which genetic and environmental factors play a role. One of the environmental risk factors is dietary iodine intake. Urinary iodine excretion in balanced diet is equally acceptable with received iodine. It’s thought that high urinary iodine excretion was associated with autoimmune thyroid diseases. We purposed to investigate whether urinary iodine level is higher in patients with HT than population. Materials and methods. 64 new patients with HT and 39 healthy volunteers were included. Age, gender, serum free-triiodothyronine (fT3), free-thyroxine (fT4), thyroid-stimulating hormone (TSH), anti thyroid peroxidase antibody (anti-TPO), anti thyroglobulin antibody (anti-TG) and urinary iodine concentration (UIC) were evaluated. Thyroid ultrasonography was performed. UIC were measured by Sandell-Kolthoff method. Results. There was no significant relationship was found between total thyroid volume and UIC in our study (p > 0.05). There was no significant difference between the fT3, fT4, anti-TPO, anti-TG and thyroid volume values of the individuals with urinary iodine levels below and above 100 μg/L. The difference between two subgroups was found to be significant only when TSH values were compared (p = 0.04). There was no significant difference between total thyroid volumes. No relation was found between HT and urine iodine levels in our study. The fact that the prevalence of HT in our country is similar to the literature makes us question the role of dietary iodine in the etiology. Conclusions. At the iodine-deficient regions such as our country relationship between urinary iodine excretion and HT needs to be investigated.


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How to Cite

Turgut, A., Erdogan, M., Yurekli, B., Sezer, E., Simsir, I., Rouhrazi, H., & Turgan, N. (2021). Is there any relationship between Hashimoto’s thyroiditis and urinary iodine level?. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 15(5), 365–370.



Original Researches