Indicators of transferrin and ferritin in overweigh and obesity children
Keywords:children, excess body weight, obesity, ferritin, transferring
AbstractBackground. Today, obesity is seen as a chronic systemic inflammation of low activity. At present, the information about the biological and clinical significance of metal proteins in the inflammatory process is being accumulated. The purpose was to study transferrin and ferritin indices in overweight and obese children. Materials and methods. We have examined the children with overweight (OW, 60 persons), obesity (Os, 45 persons), normal body weight (NBW, 60 persons), body weight deficiency (BWD, 30 persons) aged 13–18 years. Examination included anamnesis, anthropometry (height, body weight, BMI, waist-to-thigh ratio (WTR)), content of glucose, insulin, HOMA-IR calculation, content of transferrin (TF) and ferritin (Fn). For statistical analysis of the results, statistic modules of Statistica v. 6.0, MedStat and on-line SISA calculator were used. Results. In the total sample of 325 patients, OW was observed in 75 (23.1 %), Os — in 45 (13.8 %) children, BWD — in 30 (9.2 %) persons, in the rest 175 (53.8 %) — NBW. Of the overweight children, the boys prevailed and accounted for 40 (53.3 %), and 38 (55.8%) obese boys. The highest content of transferrin was observed in children aged 16–18 years (3.90 ± 0.70 g/l, n = 100; p < 0.05). The highest content of TF was recorded in children with Os II grade — 3.98 ± 0.9 g/l (n = 16) versus 3.05 ± 0.61 g/l (n = 29) (p < 0.05) in children with Os I grade. A similar trend has been established with respect to the Fn blood plasma values in examined children. Thus, higher levels of ferritin were found in children with Os II degree — 178.9 ± 22.8 ng/ml (n = 16) versus 125.8 ± 0.7 ng/ml (n = 29) (p < 0.05) in children with Os I and in children aged 16–18 years old — 176.2 ± 12.8 ng/ml (n = 25) versus 149.9 ± 11.3 ng/ml (n = 20) (p < 0.01) in children of 13–15 years old. The probable difference in gender ratios of TF and Fn is not established. Conclusions. The evaluation of systemic markers as a method of early detection of obesity is an urgent and promising direction for optimizing the obesity prevention system.
Ball GDC, Savu A, Kaul P. Changes in the prevalence of overweight, obesity, and severe obesity between 2010 and 2017 in preschoolers: A population-based study. Pediatr Obes. 2019 Jul 18. doi: 10.1111/ijpo.12561.
Centers for Disease Control and Prevention (CDC); National Center for Health Statistics. Growth Charts. Available from: http://www.cdc.gov/growthcharts/. Accessed: September 9, 2010.
Javed A, Jumean M, Murad MH, et al. Diagnostic performance of body mass index to identify obesity as defined by body adiposity in children and adolescents: a systematic review and meta-analysis. Pediatr Obes. 2015 Jun;10(3):234-44. doi: 10.1111/ijpo.242.
Ek A, Delisle Nyström C, Chirita-Emandi A, et al. A randomized controlled trial for overweight and obesity in preschoolers: the More and Less Europe study - an intervention within the STOP project. BMC Public Health. 2019 Jul 15;19(1):945. doi: 10.1186/s12889-019-7161-y.
Arora M, Nazar GP, Gupta VK, Perry CL, Reddy KS, Stigler MH. Association of breakfast intake with obesity, dietary and physical activity behavior among urban school-aged adolescents in Delhi, India: results of a cross-sectional study. BMC Public Health. 2012 Oct 17;12:881. doi: 10.1186/1471-2458-12-881.
Franklin J, Denyer G, Steinbeck KS, Caterson ID, Hill AJ. Obesity and risk of low self-esteem: a statewide survey of Australian children. Pediatrics. 2006 Dec;118(6):2481-7. doi: 10.1542/peds.2006-0511.
Dudina OO, Moisejenko RO, Zabolotna IJe, Jashhenko JuB. The dynamics of the health status of the child population. In: Ministry of Нealth of Ukraine; SI UISR Ministry of Health of Ukraine. Shhorichna dopovid' pro stan zdorov’ja naselennja, sanitarno-epidemichnu sytuaciju ta rezul'taty dijal'nosti systemy ohorony zdorov’ja Ukrai'ny. 2016 rik [Annual report on the state of public health, the sanitary-epidemiological situation and the results of the health care system of Ukraine in 2016]. Kyiv; 2017. 43-69 pp. (in Ukrainian).
Maidannyk VG, Haytovych MV, Pavlyshyn GA, Ivanko AG, Nechytaylo YuN, Ocheretko VV. Prevalence of overweight and high blood pressure among schoolchildren in different regions of Ukraine. International Journal of Pediatrics, Obstetrics and Gynecology. 2013;3(1):33-39. (in Ukrainian).
Dyachuk DD, Zabolotna IE, Yaschenko YB. Analysis of the extension of childhood expectations and evaluation of the risks of the development of diseases associated with overweight. Wiad Lek. 2018;71(3 pt 1):546-550. (in Ukrainian).
Vainilovich EG, Lushchik ML, Sretenskaia ZhL, Zapol'skii SA, Danilova LI. The incidence of abdominal obesity and the associated metabolic disturbances in the children aged 7-13 years. Problemi Endocrinologii. 2011;57(5):15-23. (in Russian).
Velychko VI, Babiy IL, Luhnikova TV, Venger YaI. Childhood obesity as a topical problem of modern pediatric practice: monitoring results in Odessa region. Odes’kij medičnij žurnal. 2011;(5):42-44. (in Ukrainian).
Halitin S, Deutsch V, Tauman R. Hepcidin, soluble transferrin receptor and IL-6 levels in obese children and adolescents with and without type 2 diabetes mellitus/impaired glucose tolerance and their association with obstructive sleep apnea. J Endocrinol Invest. 2018 Aug;41(8):969-975. doi: 10.1007/s40618-017-0823-7.
Gartner A, Berger J, Bour A, et al. Assessment of iron deficiency in the context of the obesity epidemic: importance of correcting serum ferritin concentrations for inflammation. Am J Clin Nutr. 2013 Sep;98(3):821-6. doi: 10.3945/ajcn.112.054551.
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