Implications of vitamin D deficiency during pregnancy and lactation




vitamin D, pregnancy, child health, review


Vitamin D has been a hot topic in the medical world for the last decade. The classical and non‑classical pathways of this hormone affect calcium metabolism, the immune system, cell proliferation and differentiation, infection. Vitamin D insufficiency and deficiency among pregnant women is frequent in many populations over the world. Research indicates that the adequate vitamin D level in pregnancy is optimal for maternal, fetal, and child health. Vitamin D deficiency is prevalent in Ukraine. There are few data from Ukraine about the prevalence of hypovitaminosis D in pregnancy and in the newborn. Adverse health outcomes during pregnancy are preeclampsia, gestational diabetes mellitus, and caesarean section. Consequences in newborns are low birth weight, neonatal rickets, risk of neonatal hypocalcemia, asthma, and/or type 1 diabetes mellitus. Vitamin D deficiency during pregnancy is the origin of a host of future perils for a child, especially it affects the neurodevelopment and immune system. Some of this damage caused by maternal vitamin D deficiency gets evident after 3–5 years. Therefore, the prevention of vitamin D deficiency among pregnant women is essential. The currently recommended supplementation amount of vitamin D is not sufficient to maintain a value of 25(OH)D above 30 ng/ml during pregnancy. Studies are underway to establish the recommended daily doses of vitamin D in pregnant women. Clearly, further investigation is required to study the effects of vitamin D, vitamin D supplementation for improvement in human health generally and mothers and children specifically. This review discusses vitamin D metabolism, dietary requirements and recommendations, and implications of vitamin D deficiency during pregnancy and lactation.


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Pilz S, Zittermann A, Trummer C, et al. Vitamin D testing and treatment: a narrative review of current evidence. Endocr Connect. 2019 Feb 1;8(2):R27-R43. doi:10.1530/EC-18-0432.

Christakos S, Dhawan P, Verstuyf A, Verlinden L, Carmeliet G. Vitamin D: Metabolism, Molecular Mechanism of Action, and Pleiotropic Effects. Physiol Rev. 2016 Jan;96(1):365-408. doi:10.1152/physrev.00014.2015.

Holick MF. The vitamin D deficiency pandemic: Approaches for diagnosis, treatment and prevention. Rev Endocr Metab Disord. 2017 Jun;18(2):153-165. doi:10.1007/s11154-017-9424-1.

Muscogiuri G, Altieri B, Annweiler C, et al. Vitamin D and chronic diseases: the current state of the art. Arch Toxicol. 2017 Jan;91(1):97-107. doi:10.1007/s00204-016-1804-x.

Carlson CR Jr, Uriu-Adams JY, Chambers CD, et al. Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status. J Am Coll Nutr. 2017 Jan;36(1):44-56. doi:10.1080/07315724.2016.1174091.

Wagner CL, Hollis BW. The Implications of Vitamin D Status During Pregnancy on Mother and her Developing Child. Front Endocrinol (Lausanne). 2018 Aug 31;9:500. doi:10.3389/fendo.2018.00500.

Keane JT, Elangovan H, Stokes RA, Gunton JE. Vitamin D and the Liver-Correlation or Cause? Nutrients. 2018 Apr 16;10(4):496. doi:10.3390/nu10040496.

Autier P, Boniol M, Pizot C, Mullie P. Vitamin D status and ill health: a systematic review. Lancet Diabetes Endocrinol. 2014 Jan;2(1):76-89. doi:10.1016/S2213-8587(13)70165-7.

Shin JS, Choi MY, Longtine MS, Nelson DM. Vitamin D effects on pregnancy and the placenta. Placenta. 2010 Dec;31(12):1027-1034. doi:10.1016/j.placenta.2010.08.015.

McAree T. Obesity and Vitamin D Deficiency - Current Concepts on their Impact on Pregnancy. Eur Endocrinol. 2013 Aug;9(2):125-127. doi:10.17925/EE.2013.09.02.125.

Curtis EM, Moon RJ, Harvey NC, Cooper C. Maternal vitamin D supplementation during pregnancy. Br Med Bull. 2018 Jun 1;126(1):57-77. doi:10.1093/bmb/ldy010.

Harvey NC, Holroyd C, Ntani G, et al. Vitamin D supplementation in pregnancy: a systematic review. Health Technol Assess. 2014 Jul;18(45):1-190. doi:10.3310/hta18450.

De-Regil LM, Palacios C, Lombardo LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2016 Jan 14;(1):CD008873. doi:10.1002/14651858.CD008873.pub3.

Kaushal M, Magon N. Vitamin D in pregnancy: A metabolic outlook. Indian J Endocrinol Metab. 2013 Jan;17(1):76-82. doi:10.4103/2230-8210.107862.

Palacios C, Kostiuk LK, Peña-Rosas JP. Vitamin D supplementation for women during pregnancy. Cochrane Database Syst Rev. 2019 Jul 26;7(7):CD008873. doi:10.1002/14651858.CD008873.pub4.

Baker AM, Haeri S, Camargo CA Jr, Espinola JA, Stuebe AM. A nested case-control study of midgestation vitamin D deficiency and risk of severe preeclampsia. J Clin Endocrinol Metab. 2010 Nov;95(11):5105-5109. doi:10.1210/jc.2010-0996.

Bodnar LM, Simhan HN, Catov JM, et al. Maternal vitamin D status and the risk of mild and severe preeclampsia. Epidemiology. 2014 Mar;25(2):207-14. doi:10.1097/EDE.0000000000000039.

Ojo O, Weldon SM, Thompson T, Vargo EJ. The Effect of Vitamin D Supplementation on Glycaemic Control in Women with Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis of Randomised Controlled Trials. Int J Environ Res Public Health. 2019 May 16;16(10):1716. doi:10.3390/ijerph16101716.

Hosseinzadeh-Shamsi-Anar M, Mozaffari-Khosravi H, Salami MA, Hadinedoushan H, Mozayan MR. The efficacy and safety of a high dose of vitamin d in mothers with gestational diabetes mellitus: a randomized controlled clinical trial. Iran J Med Sci. 2012 Sep;37(3):159-165.

Powell AM, Shary JR, Louden C, Ramakrishnan V, Eckard AR, Wagner CL. Association of Bacterial Vaginosis with Vitamin D in Pregnancy: Secondary Analysis from the Kellogg Pregnancy Study. AJP Rep. 2019 Jul;9(3):e226-e234. doi:10.1055/s-0039-1693163.

Vitamin D supplementation: Recommendations for Canadian mothers and infants. Paediatr Child Health. 2007 Sep;12(7):583-598.

Zipitis CS, Akobeng AK. Vitamin D supplementation in early childhood and risk of type 1 diabetes: a systematic review and meta-analysis. Arch Dis Child. 2008 Jun;93(6):512-517. doi:10.1136/adc.2007.128579.

Thorne-Lyman A, Fawzi WW. Vitamin D during pregnancy and maternal, neonatal and infant health outcomes: a systematic review and meta-analysis. Paediatr Perinat Epidemiol. 2012 Jul;26 Suppl 1(0 1):75-90. doi:10.1111/j.1365-3016.2012.01283.x.

Mannion CA, Gray-Donald K, Koski KG. Association of low intake of milk and vitamin D during pregnancy with decreased birth weight. CMAJ. 2006 Apr 25;174(9):1273-1277. doi:10.1503/cmaj.1041388.

Weiss ST, Litonjua AA. Childhood asthma is a fat-soluble vitamin deficiency disease. Clin Exp Allergy. 2008 Mar;38(3):385-387. doi:10.1111/j.1365-2222.2007.02920.x.

Wagner CL, Greer FR; American Academy of Pediatrics Section on Breastfeeding; American Academy of Pediatrics Committee on Nutrition. Prevention of rickets and vitamin D deficiency in infants, children, and adolescents. Pediatrics. 2008 Nov;122(5):1142-1152. doi:10.1542/peds.2008-1862.

Harinarayan CV, Ramalakshmi T, Prasad UV, et al. High prevalence of low dietary calcium, high phytate consumption, and vitamin D deficiency in healthy south Indians. Am J Clin Nutr. 2007 Apr;85(4):1062-1067. doi:10.1093/ajcn/85.4.1062.

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-19 30. doi:10.1210/jc.2011-0385.

McCarty CA. Sunlight exposure assessment: can we accurately assess vitamin D exposure from sunlight questionnaires? Am J Clin Nutr. 2008 Apr;87(4):1097S-101S. doi:10.1093/ajcn/87.4.1097S.

Curtis EM, Moon RJ, Harvey NC, Cooper C. Maternal vitamin D supplementation during pregnancy. Br Med Bull. 2018 Jun 1;126(1):57-77. doi:10.1093/bmb/ldy010.

Dovnik A, Mujezinović F. The Association of Vitamin D Levels with Common Pregnancy Complications. Nutrients. 2018 Jul 5;10(7):867. doi:10.3390/nu10070867.




How to Cite

Korytko, O. (2021). Implications of vitamin D deficiency during pregnancy and lactation. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 16(7), 551–555.



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