Associative links between obesity and vitamin D levels as a risk factor for primary hyperparathyroidism

Authors

DOI:

https://doi.org/10.22141/2224-0721.18.3.2022.1167

Keywords:

primary hyperparathyroidism, obesity, vitamin D

Abstract

Background. To date, the fact and mechanisms of associative links between vitamin D deficiency and primary hyperparathyroidism (PGPT) have been established. In turn, the level of 25(OH)D is influenced by climatic conditions and the presence of obesity (Ob). These set the purpose of the study — to determine the supply of vitamin D in patients with endocrine disorders li­ving in the climate in Ukraine, and to assess the impact of Ob on vitamin D levels and the development of hypercalcemia — signs of PGPT. Materials and methods. BMI, serum calcium (Ca) and vitamin D levels in 145 patients who were in the endocrinology clinic for va­rious endocrine pathologies were studied. The frequency of vitamin insufficiency and vitamin D efficiency, hypercalcemia in groups with and without obesity was analyzed. Results. The proportion of obese in the general group was 33.8 %, among men — 28.57 %, among women — 35.04 % (p < 0.05). The le­vel of Ca in the blood was 2.39 ± 0.02 mmol/l, high Ca level occurred in 16.55 %, and Ob — іn 49 (33.49 %) patients. Against the background of Ob, the level of Ca was 2.42 ± 0.02, and in non-obese people — 2.38 ± 0.02 (p > 0.05). Average level of vitamin D in the blood in the general group was 22.95 ± 0.73 mg/ml and was probably lower in indivi­duals with Ob (20.95 ± 1.39 vs. 24.09 ± 0.81 mg/ml in groups without Ob, p < 0.05). Distribution of the disease by the degree of provision of vitamin D showed that in a cohort with low security vitamin D and the presence of Ob subgroup with a deficiency of vitamin D (20–29 ng/ml) was almost twice as large as the similar subgroup without Ob. As follows, the presence of Ob in patients with endocrine pathology has no probable effect on the incidence of hypercalcemia, but is associated with a probable decrease in the level of vitamin D in the blood with a predominance of subgroups with vitamin D deficiency, while in the group without Ob. Conclusions. In the climatic conditions of Ukraine and the functioning health care system in patients with endocrine pathology, the average level of vitamin D is within its deficiency (22.95 ± 0.73 ng/ml). The presence of obesity in patients with endocrine pathology is associated with a probably lower supply of vitamin D, almost doubling the subgroup with vitamin deficiency (< 20 ng/ml). The combination of obesity and vitamin D deficiency should be considered as a risk factor for primary hyperparathyroidism in patients with endocrine patho­logy. Such patients need regular monitoring of blood calcium and parathyroid hormone, as well as medical support for vitamin D.

Downloads

Download data is not yet available.

References

Souberbielle JC, Bienaimé F, Cavalier E, Cormier C. Vitamin D and primary hyperparathyroidism (PHPT). Ann Endocrinol (Paris). 2012 Jun;73(3):165-169. doi:10.1016/j.ando.2012.04.008.

Walker MD, Bilezikian JP. Vitamin D and primary hyperparathyroidism: more insights into a complex relationship. Endocrine. 2017 Jan;55(1):3-5. doi:10.1007/s12020-016-1169-1.

Eastell R, Brandi ML, Costa AG, D'Amour P, Shoback DM, Thakker RV. Diagnosis of asymptomatic primary hyperparathyroidism: proceedings of the Fourth International Workshop. J Clin Endocrinol Metab. 2014 Oct;99(10):3570-3579. doi:10.1210/jc.2014-1414.

Walker MD, Cong E, Lee JA, et al. Low vitamin D levels have become less common in primary hyperparathyroidism. Osteoporos Int. 2015 Dec;26(12):2837-2843. doi:10.1007/s00198-015-3199-6.

Sempos CT, Binkley N. 25-Hydroxyvitamin D assay standardisation and vitamin D guidelines paralysis. Public Health Nutr. 2020 May;23(7):1153-1164. doi:10.1017/S1368980019005251.

Lindeman BM, Pesce CE, Tsai HL, et al. Lower vitamin D levels in surgical hyperparathyroidism versus thyroid patients. Am Surg. 2014 May;80(5):505-510.

Liu Y, Guo S, Wu J, et al. Changes in clinical patterns of Chinese patients with primary hyperparathyroidism in the past 12 years: a single-center experience. Endocr Connect. 2021 Nov 5;10(11):1428-1434. doi:10.1530/EC-21-0382.

Jorde R, Sneve M, Hutchinson M, Emaus N, Figenschau Y, Grimnes G. Tracking of serum 25-hydroxyvitamin D levels during 14 years in a population-based study and during 12 months in an intervention study. Am J Epidemiol. 2010 Apr 15;171(8):903-908. doi:10.1093/aje/kwq005.

Bjerg LN, Halgreen JR, Hansen SH, Morris HA, Jørgensen NR. An evaluation of total 25-hydroxyvitamin D assay standardization: Where are we today? J Steroid Biochem Mol Biol. 2019 Jun;190:224-233. doi:10.1016/j.jsbmb.2019.03.015.

Van der Wielen RP, Löwik MR, van den Berg H, et al. Serum vitamin D concentrations among elderly people in Europe. Lancet. 1995 Jul 22;346(8969):207-210. doi:10.1016/s0140-6736(95)91266-5.

Povoroznyuk V, Pankiv I. Vitamin D Deficiency and insufficiency in population of Bukovyna and Subcarpathia. Mìžnarodnij endokrinologìčnij žurnal. 2016;(76):22-25. doi:10.22141/2224-0721.4.76.2016.77793. (in Ukrainian).

Kriklyevets LS, Kriklyvets SYu, Latash SO, Medvedev OV. On the level of vitamin D in the selective cought of rheumatological patients of the consultative polyclinic of Zhytomyr. Ukrainian journal of rheumatology. 2018;(73):72-72. (in Ukrainian).

Kaminskyi OV, Pankiv VI, Pankiv IV, Afanasyev DE. Vitamin D content in population of radiologically contaminated areas in Chernivtsi oblast (pilot project). Probl Radiac Med Radiobiol. 2018 Dec;23:442-451. doi:10.33145/2304-8336-2018-23-442-451.

Goncharova OA, Arkhipkina TL, Bondarenko VO, Lyubimova LP. Vitamin D status and features of the immune status in women with autoimmune thyroiditis in the postmenopausal period. Clinical Endocrinology and Endocrine Surgery. 2020;(69):51-56. doi:10.30978/CEES-2020-1-51. (in Ukrainian).

Published

2022-05-28

How to Cite

Goncharova, O., & Dubovik, V. (2022). Associative links between obesity and vitamin D levels as a risk factor for primary hyperparathyroidism. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 18(3), 184–187. https://doi.org/10.22141/2224-0721.18.3.2022.1167

Issue

Section

Literature Review

Most read articles by the same author(s)

<< < 1 2