Magnesium deficiency in type 2 diabetes mellitus and its effect on blood glucose control and diabetes complications




type 2 diabetes mellitus, magnesium, microalbuminuria


Background. Diabetes has become more often in all over the world, magnesium is an essential element of the body and has lots of vital functions. There has been a trend to investigate magnesium’s effect on type 2 diabetes pathogenesis and its complications. Still, more data is needed to reveal magnesium and T2 diabetes mellitus (DM) association, therefore we aimed to investigate how common magnesium deficiency in Turkish T2DM patients, and its effect on diabetes control and diabetes complications. Materials and methods. 296 patients with type 2 DM and 96 healthy controls aged between 18–65 years were enrolled in the study. After exclusion criteria, T2DM patients were divided into 2 groups according to magnesium deficiency, metabolic and physical properties of the groups were compared. Also, hypertension, metabolic syndrome, coronary artery disease, and microalbuminuria were also compared according to magnesium deficiency. Results. Magnesium deficiency was found 35.5 % (86/242) in patients with type 2 DM, 4.1 % (4/96) in the control group. Magnesium deficiency was more in female patients (64/86, 74.4 %), male patients had more normal magnesium levels 89/166, 53.6 %) (p < 0.01). Hypomagnеsemia patients with T2 DM didn’t show difference in HbA1c (9.0 ± 1.9 % vs 8.8 ± 1.6 %, p = 0.35), and fasting blood glucose levels (197.24 ± 87.25 vs 177.85 ± 57.22 mg/dl, p = 0.14). Hypomagnеsemia patients with T2DM had significantly higher hyperlipidemia levels (48.8 % (42/86) vs 41.0 % (64/156), p = 0.04). Metabolic syndrome (89.0 % (73/82) vs 83.1 % (123/148), p = 0.22) and coronary artery syndrome (39.5 % (34/86) vs 35.9 % (56/156), p = 0.85) didn’t differ between groups. Hypertension (81.4 % (70/86) vs 67.9 (60/156), p = 0.04) and microalbuminuria (66.7 % (38/57) vs 43.7 (58/119), p = 0.03) were significantly higher in the hypomagnеsemia T2DM group. Conclusions. Magnesium deficiency is not rare in T2DM, however, this deficiency didn’t impact blood glucose control at a significant level in current study, on the other hand, hypertension, microalbuminuria, and hyperlipidemia components of diabetes have been shown to increase with magnesium deficiency.


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de Baaij JH, Hoenderop JG, Bindels RJ. Magnesium in man: implications for health and disease. Physiol Rev. 2015 Jan;95(1):1-46. doi: 10.1152/physrev.00012.2014.

Zhang X, Xia J, Del Gobbo LC, Hruby A, Dai Q, Song Y. Serum magnesium concentrations and all-cause, cardiovascular, and cancer mortality among U.S. adults: Results from the NHANES I Epidemiologic Follow-up Study. Clin Nutr. 2018 Oct;37(5):1541-1549. doi: 10.1016/j.clnu.2017.08.021.

Wesselink E, Kok DE, Bours MJL, et al. Vitamin D, magnesium, calcium, and their interaction in relation to colorectal cancer recurrence and all-cause mortality. Am J Clin Nutr. 2020 May 1;111(5):1007-1017. doi: 10.1093/ajcn/nqaa049.

Larsson SC, Traylor M, Burgess S, et al; MEGASTROKE project of the International Stroke Genetics Consortium. Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study. Neurology. 2019 Feb 26;92(9):e944-e950. doi: 10.1212/WNL.0000000000007001.

Shamnani G, Bhartiy SS, Jiwane R, Gupta V, Verma N, Verma D. Correlation of Serum Magnesium with Insulin Resistance in North Indian Adult Population. Curr Diabetes Rev. 2020;16(3):254-261. doi: 10.2174/1573399814666181016164432.

Luo X, Cai WY, Ma HL, et al. Associations of Serum Magnesium With Insulin Resistance and Testosterone in Women With Polycystic Ovary Syndrome. Front Endocrinol (Lausanne). 2021 Jun 23;12:683040. doi: 10.3389/fendo.2021.683040.

Chutia H, Lynrah KG. Association of Serum Magnesium Deficiency with Insulin Resistance in Type 2 Diabetes Mellitus. J Lab Physicians. 2015 Jul-Dec;7(2):75-8. doi: 10.4103/0974-2727.163131.

ELDerawi WA, Naser IA, Taleb MH, Abutair AS. The Effects of Oral Magnesium Supplementation on Glycemic Response among Type 2 Diabetes Patients. Nutrients. 2018 Dec 26;11(1):44. doi: 10.3390/nu11010044.

Dasgupta A, Sarma D, Saikia UK. Hypomagnesemia in type 2 diabetes mellitus. Indian J Endocrinol Metab. 2012 Nov;16(6):1000-3. doi: 10.4103/2230-8210.103020.

Azad KM, Sutradhar SR, Khan NA, et al. Serum magnesium in hospital admitted diabetic patients. Mymensingh Med J. 2014 Jan;23(1):28-34.

Wälti MK, Zimmermann MB, Spinas GA, Hurrell RF. Low plasma magnesium in type 2 diabetes. Swiss Med Wkly. 2003 May 17;133(19-20):289-92.

Lopez-Ridaura R, Willett WC, Rimm EB, Liu S, Stampfer MJ, Manson JE, Hu FB. Magnesium intake and risk of type 2 diabetes in men and women. Diabetes Care. 2004 Jan;27(1):134-40. doi: 10.2337/diacare.27.1.134.

Kao WH, Folsom AR, Nieto FJ, Mo JP, Watson RL, Brancati FL. Serum and dietary magnesium and the risk for type 2 diabetes mellitus: the Atherosclerosis Risk in Communities Study. Arch Intern Med. 1999 Oct 11;159(18):2151-9. doi: 10.1001/archinte.159.18.2151.

Schutten JC, Gomes-Neto AW, Navis G, et al. Lower Plasma Magnesium, Measured by Nuclear Magnetic Resonance Spectroscopy, is Associated with Increased Risk of Developing Type 2 Diabetes Mellitus in Women: Results from a Dutch Prospective Cohort Study. J Clin Med. 2019 Feb 1;8(2):169. doi: 10.3390/jcm8020169.

Kostov K. Effects of Magnesium Deficiency on Mechanisms of Insulin Resistance in Type 2 Diabetes: Focusing on the Processes of Insulin Secretion and Signaling. Int J Mol Sci. 2019 Mar 18;20(6):1351. doi: 10.3390/ijms20061351.

Gommers LM, Hoenderop JG, Bindels RJ, de Baaij JH. Hypomagnesemia in Type 2 Diabetes: A Vicious Circle? Diabetes. 2016 Jan;65(1):3-13. doi: 10.2337/db15-1028.

Manialawy Y, Khan SR, Bhattacharjee A, Wheeler MB. The magnesium transporter NIPAL1 is a pancreatic islet-expressed protein that conditionally impacts insulin secretion. J Biol Chem. 2020 Jul 17;295(29):9879-9892. doi: 10.1074/jbc.RA120.013277.

Günther T. The biochemical function of Mg²+ in insulin secretion, insulin signal transduction and insulin resistance. Magnes Res. 2010 Mar;23(1):5-18. doi: 10.1684/mrh.2009.0195.

Zahra H, Berriche O, Mizouri R, et al. Plasmatic Magnesium Deficiency in 101 Outpatients Living with Type 2 Diabetes Mellitus. Clin Pract. 2021 Oct 27;11(4):791-800. doi: 10.3390/clinpract11040095.

Odusan OO, Familoni OB, Odewabi AO, Idowu AO, Adekolade AS. Patterns and Correlates of Serum Magnesium Levels in Subsets of Type 2 Diabetes Mellitus Patients in Nigeria. Indian J Endocrinol Metab. 2017 May-Jun;21(3):439-442. doi: 10.4103/ijem.IJEM_190_16.

Louvet L, Bazin D, Büchel J, Steppan S, Passlick-Deetjen J, Massy ZA. Characterisation of calcium phosphate crystals on calcified human aortic vascular smooth muscle cells and potential role of magnesium. PLoS One. 2015 Jan 21;10(1):e0115342. doi: 10.1371/journal.pone.0115342.

Villa-Bellosta R. Impact of magnesium:calcium ratio on calcification of the aortic wall. PLoS One. 2017 Jun 1;12(6):e0178872. doi: 10.1371/journal.pone.0178872.

Correa S, Guerra-Torres XE, Waikar SS, Mc Causland FR. Serum Magnesium, Blood Pressure, and Risk of Hypertension and Chronic Kidney Disease Progression in the CRIC Study. Hypertension. 2021 Dec;78(6):1771-1780. doi: 10.1161/HYPERTENSIONAHA.121.17694.

Kaliaperumal R, Venkatachalam R, Nagarajan P, Sabapathy SK. Association of Serum Magnesium with Oxidative Stress in the Pathogenesis of Diabetic Cataract. Biol Trace Elem Res. 2021 Aug;199(8):2869-2873. doi: 10.1007/s12011-020-02429-9.




How to Cite

Karatas, S., Hacıoglu, Y., & Kose, Şennur. (2022). Magnesium deficiency in type 2 diabetes mellitus and its effect on blood glucose control and diabetes complications. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 18(2), 104–108.



Original Researches