Primary hyperparathyroidism: optimize the detection and monitoring (organizational aspects)
Keywords:primary hyperparathyroidism, diagnosis, monitoring
Background. The relevance of the study is due to the fact that undiagnosed primary hyperparathyroidism (PHPT) significantly increases the risk of osteoporosis and fractures, nephrolithiasis and renal failure, reducing the quality of life of patients. All this necessitates the improvement of the organizational system of disease detection and monitoring. The purpose of the study was to assess the incidence of hypercalcemia (HCa) in patients with endocrine disorders and to determine the sex and age composition in the subgroup with HA. Materials and methods. The frequency of HCa (by total calcium and ionized calcium levels) in 107 patients with endocrine pathology examined in endocrine clinic during November and December 2021 was determined, gender and age characteristics, the nature of endocrine pathology in the subgroup with HCa were characterized. The level of total calcium was determined by photocolorimetric method using a photometer ”Solar PM 2111“, set ”SpL“ (Ukraine), the level of ionized calcium was determined by a calculated method depending on the concentration of albumin. Results. Among patients with endocrine pathology, HCa occurs in approximately 30 % of cases. The ratio between men and women is similar in the subgroups with normo- and hypercalcemia. The presence of endocrine comorbidity in patients increases the risk of HCa. The obtained results show that the existing organization of work in Ukraine to identify and monitor patients with HCa needs to be optimized. As a sample, we can use the conceptual model of action of a primary care physician developed by American authors, aimed at optimizing the work on the detection and monitoring of PHPT. Conclusions. For Ukraine, the problem of improving the organizational system for detection and monitoring of HCa, which should include deadlines for monitoring blood calcium levels, periodicity of research, further monitoring of people with HCa, provide communications to primary and specialized physicians.
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