Effectiveness of vitex agnus castus extract in the treatment of primary dysmenorrhea

Authors

DOI:

https://doi.org/10.22141/2224-0721.18.1.2022.1141

Keywords:

menstrual pain, hormonal balance, primary dysmenorrhea

Abstract

Background. Primary dysmenorrhea (PD) is one of the most common types of gynecological pathology and is observed in 31–52 % of young women, in 10 % of them the pain is so intense that leads to disability. In the pathogenesis of PD consider a representative of eicosanoids — thromboxane A2 with a pronounced vasoconstrictor effect. The article presents the results of clinical and hormonal examination of women with PD and developed on this basis a method of treatment. The purpose was to develop and evaluate the effectiveness of treatment of PD, taking into account the multicomponent pathogenesis of the disease. Materials and methods. There were 60 women observation, randomly divided into two groups: 30 women with PD (main group) and 30 healthy women (control group). PD was diagnosed on the basis of patients’ complaints of painful menstruation and related symptoms, excluding organic gynecological pathology and diseases of the internal organs in consultation with a physician and endocrinologist. Treatment of patients with PD was performed with a combined drug, which includes a standardized extract of Vitex agnus castus L., indole-3-carbinol, 3,3-diindolyl-methane, passionflower extract, California escholzia extract. Results. As a result of treatment in patients with PD significantly reduced the intensity of pain, and 60 % completely disappeared pain, all disappeared fear of waiting for the next menstruation, significantly reduced the manifestations of autonomic vascular (from 17 % of patients to 3 %), autonomic (from 10 % of patients to 0 %), metabolic and endocrine (from 13 % of patients to 0 %) disorders and disorders of the emotional and mental sphere (from 23 % of patients to 7 %), no patient had a combination of symptoms. Conclusions. Given the safety, high therapeutic efficacy, the drug based on Vitex agnus castus extract can be recommended for the treatment of young patients with PD lasting at least 3 months.

Downloads

Download data is not yet available.

References

Armour M, Parry K, Manohar N, et al. The Prevalence and Academic Impact of Dysmenorrhea in 21,573 Young Women: A Systematic Review and Meta-Analysis. J Womens Health (Larchmt). 2019 Aug;28(8):1161-1171. doi: 10.1089/jwh.2018.7615.

Matthewman G, Lee A, Kaur JG, Daley AJ. Physical activity for primary dysmenorrhea: a systematic review and meta-analysis of randomized controlled trials. Am J Obstet Gynecol. 2018 Sep;219(3):255.e1-255.e20. doi: 10.1016/j.ajog.2018.04.001.

Fernández-Martínez E, Abreu-Sánchez A, Velarde-García JF, Iglesias-López MT, Pérez-Corrales J, Palacios-Ceña D. Living with Restrictions. The Perspective of Nursing Students with Primary Dysmenorrhea. Int J Environ Res Public Health. 2020 Nov 17;17(22):8527. doi: 10.3390/ijerph17228527.

Burnett M, Lemyre M. No. 345-Primary Dysmenorrhea Consensus Guideline. J Obstet Gynaecol Can. 2017 Jul;39(7):585-595. doi: 10.1016/j.jogc.2016.12.023.

Bajalan Z, Moafi F, MoradiBaglooei M, Alimoradi Z. Mental health and primary dysmenorrhea: a systematic review. J Psychosom Obstet Gynaecol. 2019 Sep;40(3):185-194. doi: 10.1080/0167482X.2018.1470619.

Li AD, Bellis EK, Girling JE, et al. Unmet Needs and Experiences of Adolescent Girls with Heavy Menstrual Bleeding and Dysmenorrhea: A Qualitative Study. J Pediatr Adolesc Gynecol. 2020 Jun;33(3):278-284. doi: 10.1016/j.jpag.2019.11.007.

Rafique N, Al-Sheikh MH. Prevalence of primary dysmenorrhea and its relationship with body mass index. J Obstet Gynaecol Res. 2018 Sep;44(9):1773-1778. doi: 10.1111/jog.13697.

Ryan SA. The Treatment of Dysmenorrhea. Pediatr Clin North Am. 2017 Apr;64(2):331-342. doi: 10.1016/j.pcl.2016.11.004.

Heskes AM, Sundram TCM, Boughton BA, et al. Biosynthesis of bioactive diterpenoids in the medicinal plant Vitex agnus-castus. Plant J. 2018 Mar;93(5):943-958. doi: 10.1111/tpj.13822.

Sogame M, Naraki Y, Sasaki T, et al. Quality Assessment of Medicinal Product and Dietary Supplements Containing Vitex agnus-castus by HPLC Fingerprint and Quantitative Analyses. Chem Pharm Bull (Tokyo). 2019;67(6):527-533. doi: 10.1248/cpb.c18-00725.

Vo QV, Mechler A. In Silico Study of the Radical Scavenging Activities of Natural Indole-3-Carbinols. J Chem Inf Model. 2020 Jan 27;60(1):316-321. doi: 10.1021/acs.jcim.9b00917.

Escobar LK. Two new species of Passsiflora (Passifloraceae) from Northern South America. Phytologia. 1989;66(1)80-82. doi: 10.5962/bhl.part.9803.

Rolland A, Fleurentin J, Lanhers MC, Misslin R, Mortier F. Neurophysiological effects of an extract of Eschscholzia californica Cham. (Papaveraceae). Phytother Res. 2001 Aug;15(5):377-81. doi: 10.1002/ptr.884.

Semenyna HB, Shatylovych KL, Fartushok TV, Komissarova OS, Yurchyshyn OM. A new approach to the combination therapy of polycystic ovary syndrome. World of Medicine and Biology. 2020; (72):125-129. doi: 10.26724/2079-8334-2020-2-72-125-129.

Downloads

Published

2022-06-29

How to Cite

H.B., S., & O.O., K. (2022). Effectiveness of vitex agnus castus extract in the treatment of primary dysmenorrhea. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 18(1), 17–21. https://doi.org/10.22141/2224-0721.18.1.2022.1141

Issue

Section

Original Researches