Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome

Authors

  • T.L. Arkhypkina State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine https://orcid.org/0000-0001-5529-7583
  • V.A. Bondarenko State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine https://orcid.org/0000-0002-9254-3875
  • L.P. Lyubimovа State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine https://orcid.org/0000-0003-2984-6969
  • I.O. Bielkina State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine https://orcid.org/0000-0003-0439-0969
  • N.F. Velichko State Institution “V. Danilevsky Institute for Endocrine Pathology Problems of the National Academy of Medical Sciences of Ukraine”, Kharkiv, Ukraine https://orcid.org/0000-0002-3115-8076

DOI:

https://doi.org/10.22141/2224-0721.17.6.2021.243206

Keywords:

polycystic ovary syndrome, vitamin D, nitric oxide, arginine, C-reactive protein, interleukin-6, homocysteine

Abstract

Background. The study was aimed to determine the correlation between the blood concentration of vitamin D and factors that influence the function of the endothelium and the hemodynamic of gonads in women with polycystic ovary syndrome (PCOS). Material and methods. Sixty women aged from 18 to 26 years were examined: 30 women with a diagnosis of PCOS and 30 healthy women. The blood serum concentration of vitamin D, C-reactive protein (CRP), interleukin-6 (IL-6), homocysteine (Hcy), nitrites/nitrates (NOx), and arginine were investigated. Maximum systolic velocity (Vmax), resistance index (RI), and pulsatility index (PI) were measured with Doppler ultrasound. Cholecalciferol was used in a dose of 4000 IU per day for 12 weeks for the correction of deficiency of vitamin D. Results. The patients with PCOS were found to have a lower (Р < 0.001) average vitamin D than healthy women. The reduction of vitamin D concentration was combined with an increase (P < 0.001) in the average concentration of NOx and a decrease in arginine. It was found a positive association between vitamin D and arginine (r = 0.391; P < 0.05), between NOx and CRP (r = 0.432; P < 0.02), IL-6 (r = 0.476; P < 0.01), Vmax (r = 0.383; P < 0.05), RI (r = 0.369; P < 0.05), PI (r = 0.380; P < 0.05) and reverse correlation with arginine (r = –0.375; P < 0.05). It was not found an association between NOx and vitamin D (r = 0.207; P > 0.05), Hcy (r = 0.176; P > 0.05); between vitamin D and Vmax (r = 0.231; P > 0.05), RI (r = 0.201; P > 0.05), PI (r = 0.181; P > 0.05). The therapy of cholecalciferol level was accompanied by an increase (P < 0.001) in concentrations of vitamin D, arginine (P < 0.05) and a decrease in NOx (P < 0.02), IL-6 (P < 0.05), SRP (P < 0.001), Hcy (P < 0.001), Vmax (P < 0.001), RI (P < 0.001), PI (P < 0.01), quantity of antral follicles (P < 0.001), and the growth of follicles (P < 0.001). However, none of the studied indicators reached the indicators in healthy women. Conclusions. The deficiency of vitamin D is associated with increased markers of chronic inflammation, homocysteine, nitrate/nitrites, reduced concentration of arginine that provokes the development of endothelium dysfunction and, therefore, the hemodynamics disorders and folliculogenesis in the ovary.

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References

Yavuz Taşlipinar M, Kiliç N, et al. Endothelial dysfunction and insulin resistance in young women with polycystic ovarian syndrome. Turk J Med Sci. 2014;44(5):787-91. doi: 10.3906/sag-1401-4.

Dube R. Does endothelial dysfunction correlate with endocrinal abnormalities in patients with polycystic ovary syndrome? Avicenna J Med. 2016 Oct-Dec;6(4):91-102. doi: 10.4103/2231-0770.191445.

Tabrizi R, Akbari M, Lankarani KB, Heydari ST, Kolahdooz F, Asemi Z. The effects of vitamin D supplementation on endothelial activation among patients with metabolic syndrome and related disorders: a systematic review and meta-analysis of randomized controlled trials. Nutr Metab (Lond). 2018 Nov 29;15:85. doi: 10.1186/s12986-018-0320-9.

Vanchinathan V, Lim HW. A dermatologist's perspective on vitamin D. Mayo Clin Proc. 2012 Apr;87(4):372-80. doi: 10.1016/j.mayocp.2011.12.010.

Aghamohammadzadeh N, Dolatkhah N, Hashemian M, Shakouri SK, Hasanpour S. The relationship between serum 25-hydroxyvitamin D and blood pressure and quality of life in overweight and obese patients with type 2 diabetes mellitus compared with healthy subjects. Caspian J Intern Med. 2020;11(3):267-277. doi: 10.22088/cjim.11.3.267.

Liew H, AlvinTan WK, Chew DEK. Vitamin D and the endothelium: basic, translational and clinical research updates. IJC Metabolic Endocrine. 2014;4:4-17. doi: 10.1016/j.ijcme.2014.06.003.

Kim DH, Meza CA, Clarke H, Kim JS, Hickner RC. Vitamin D and Endothelial Function. Nutrients. 2020 Feb 22;12(2):575. doi: 10.3390/nu12020575.

Krishna SM. Vitamin D as A Protector of Arterial Health: Potential Role in Peripheral Arterial Disease Formation. Int J Mol Sci. 2019 Oct 3;20(19):4907. doi: 10.3390/ijms20194907.

Qian J, Fulton D. Post-translational regulation of endothelial nitric oxide synthase in vascular endothelium. Front Physiol. 2013 Dec 13;4:347. doi: 10.3389/fphys.2013.00347.

Förstermann U, Sessa WC. Nitric oxide synthases: regulation and function. Eur Heart J. 2012 Apr;33(7):829-37, 837a-837d. doi: 10.1093/eurheartj/ehr304.

Urbanovych A. Polycystic Ovary Syndrome in Every Day Practice. International Journal of Endocrinology (Ukraine). 2018;14(1):40-45. doi: 10.22141/2224-0721.14.1.2018.127090. (in Ukrainian).

Banjarnahor S, Rodionov RN, König J, Maas R. Transport of L-Arginine Related Cardiovascular Risk Markers. J Clin Med. 2020 Dec 8;9(12):3975. doi: 10.3390/jcm9123975.

Arkhypkina TL, Karpenko NA, Lyubimovа LP, et al. Effect of L-arginine therapy on the level of stable metabolites of nitric oxide cycle, endothelial dysfunction markers and indicators of ovarian hemodynamics at women with polycystic ovary syndrome. Problems of Endocrine Pathology. 2017;59(1):7-17. doi: 0.21856/j-PEP.2017.1.01. (in Ukrainian).

Amer M, Qayyum R. The relationship between 25-hydroxyvitamin D and homocysteine in asymptomatic adults. J Clin Endocrinol Metab. 2014 Feb;99(2):633-8. doi: 10.1210/jc.2013-3262.

Pham TM, Ekwaru JP, Mastroeni SS, Mastroeni MF, Loehr SA, Veugelers PJ. The Effect of Serum 25-Hydroxyvitamin D on Elevated Homocysteine Concentrations in Participants of a Preventive Health Program. PLoS One. 2016 Aug 22;11(8):e0161368. doi: 10.1371/journal.pone.0161368.

Dambala K, Paschou SA, Michopoulos A, et al. Biomarkers of Endothelial Dysfunction in Women With Polycystic Ovary Syndrome. Angiology. 2019 Oct;70(9):797-801. doi: 10.1177/0003319719840091.

Pankiv V, Pankiv I. Effect of cholecalciferol supplementation on bone turnover markers in children and adolescents with type 1 diabetes mellitus. Journal of the Endocrine Society. 2021;5(Suppl 1):A274. doi: 10.1210/jendso/bvab048.556.

Haussler MR, Whitfield GK, Kaneko I, et al. Molecular mechanisms of vitamin D action. Calcif Tissue Int. 2013 Feb;92(2):77-98. doi: 10.1007/s00223-012-9619-0.

Semenyna GB, Pankiv VI, Pashkovska NV, Korutko OO, Pankiv IV. Ovarian factors in the pathogenesis of chronic anovulation in polycystic ovary syndrome. Problems of endocrine pathology. 2021;71(1):65-71. doi: 10.21856/j-PEP.2020.1.09.

Holick MF, Binkley NC, Bischoff-Ferrari HA, et al; Endocrine Society. Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011 Jul;96(7):1911-30. doi: 10.1210/jc.2011-0385.

Behmanesh N, Abedelahi A, Charoudeh HN, Alihemmati A. Effects of vitamin D supplementation on follicular development, gonadotropins and sex hormone concentrations, and insulin resistance in induced polycystic ovary syndrome. Turk J Obstet Gynecol. 2019 Sep;16(3):143-150. doi: 10.4274/tjod.galenos.2019.46244.

Published

2022-01-04

How to Cite

Arkhypkina, T., Bondarenko, V., Lyubimovа L., Bielkina, I., & Velichko, N. (2022). Vitamin D role in endothelial dysfunction development in patients with polycystic ovarian syndrome. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), 17(6), 459–464. https://doi.org/10.22141/2224-0721.17.6.2021.243206

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Section

Original Researches