Correlation of vitamin D level with thyroid status and TSH antibody titers in patients with Graves’ disease
Keywords:Graves’ disease, vitamin D, TSH-Ab titers
Background. Various studies have shown the association of vitamin D deficiency with autoimmune diseases. Studies have found that vitamin D levels in patients with autoimmune thyroid diseases including Graves’ disease were lower than that in patients with non-autoimmune thyroid diseases such as toxic nodular goiter. Some studies have reported no such relationship between vitamin D level and autoimmune thyroid diseases. The purpose of the study: to compare serum vitamin D level in patients with Graves’ disease versus age and sex matched controls, to assess the correlation of vitamin D with thyroid status and thyrotropin receptor antibody titers. Materials and methods. 48 patients with Graves’ disease and 24 age and sex matched healthy individuals were recruited. Hormonal investigations that included serum thyroid stimulating hormone (TSH), free thyroxine (fT4), free triiodothyronine (fT3), as well as calcium, 25-hydroxyvitamin D (25(OH)D), parathyroid hormone (PTH), thyroid stimulating hormone receptor antibody (TSH-Ab) were done for all subjects. Results. The patients with Graves’ disease had significantly lower 25(OH)D levels (16.3 ± 1.4 ng/ml) as compared to control subjects (22.8 ± 1.6 ng/ml) (p = 0.024). TSH levels and TSH-Ab titers differed significantly between vitamin D deficient Graves’ disease group (25(OH)D < 20 ng/ml) and vitamin D non deficient Graves’ disease group (25(OH)D ≥ 20 ng/ml). Thyroid volume did not differ significantly between these groups. Serum vitamin D level correlated significantly with TSH and TSH-Ab titers in patients with Graves’ disease. Conclusions. Serum vitamin D levels are significantly lower in patients with Graves’ disease. Significant correlation between vitamin D and TSH and TSH-Ab titers was found in these patients.
Villa A, Corsello A, Cintoni M, et al. Effect of vitamin D supplementation on TSH levels in euthyroid subjects with autoimmune thyroiditis. Endocrine. 2020;10.1007/s12020-020-02274-9. doi:10.1007/s12020-020-02274-9.
Krysiak R, Kowalcze K, Okopień B. The effect of vitamin D on thyroid autoimmunity in euthyroid men with autoimmune thyroiditis and testosterone deficiency. Pharmacol Rep. 2019;71(5):798-803. doi:10.1016/j.pharep.2019.04.010.
Misharin A, Hewison M, Chen CR, et al. Vitamin D deficiency modulates Graves' hyperthyroidism induced in BALB/c mice by thyrotropin receptor immunization. Endocrinology. 2009;150(2):1051-1060. doi:10.1210/en.2008-1191.
Pankiv VI, Yuzvenko TYu, Pankiv IV. Type 2 diabetes mellitus and subclinical hypothyroidism: focusing on the role of cholecalciferol. Problems of Endocrine Pathology. 2019;(2):46-51. doi:10.21856/j-PEP.2019.2.07.
Li X, Wang G, Lu Z, Chen M, Tan J, Fang X. Serum 25-hydroxyvitamin D predict prognosis in radioiodine therapy of Graves' disease. J Endocrinol Invest. 2015;38(7):753-759. doi:10.1007/s40618-015-0252-4.
Mangaraj S, Choudhury AK, Swain BM, Sarangi PK, Mohanty BK, Baliarsinha AK. Evaluation of Vitamin D Status and its Impact on Thyroid Related Parameters in New Onset Graves' Disease- A Cross-sectional Observational Study. Indian J Endocrinol Metab. 2019;23(1):35-39. doi:10.4103/ijem.IJEM_183_18.
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Copyright (c) 2020 V.I. Pankiv, T.Yu. Yuzvenko, S.M. Koval, K. Singh, I.V. Pankiv, Tarun Sehgal, O.M. Lytvinova
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