Vitamin D: new aspects of application, effective doses. The current state of the problem
Keywords:vitamin D, physiological role, deficiency, dosage, efficacy, Dekristol® 20°000
In addition to the classic role of vitamin D in maintaining the normal state of the musculoskeletal system in the last decade, there is evidence that reduced serum concentrations of 25(OH)D are associated with a number of extraskeletal diseases (diabetes mellitus, hypertension, thyroid diseases, age-related cognitive decline, dysfunction of the immune and reproductive systems, etc.). Prevention of these diseases is achieved with significantly higher concentrations of 25(OH)D in the serum than those necessary to maintain normal bone tissue, regulate absorption and maintain calcium homeostasis. To ensure the concentration of the circulating form of vitamin D — 25(OH)D in the serum at a level that ensures optimal functioning, you need a higher consumption of this vitamin. Decreased blood concentration of vitamin D (< 30 ng/ml) is observed in 92 % of the adult population of Ukraine, regardless of the season. The causes of vitamin D deficiency are the low efficiency of its endogenous synthesis in the skin due to insufficient insolation and inadequate intake of this vitamin with food. Due to the half-life of vitamin D of about two months, periodic weekly or monthly intake of total doses of cholecalciferol provides the same values in the serum as daily intake. The review of the literature considers the importance of vitamin D deficiency and deficiency in disorders of many systems of the human body and the development of various pathological conditions, which justifies the wider use of methods to correct the status of vitamin D. Despite the need for large-scale randomized clinical trials to determine the use of vitamin D, now there is no doubt that the normalization of the level of 25(OH)D in the serum is required at all age stages of ontogenesis.
Yaribeygi H, Maleki M, Sathyapalan T, et al. The molecular mechanisms by which vitamin D improve glucose homeostasis: A mechanistic review. Life Sci. 2020 Mar 1;244:117305. doi:10.1016/j.lfs.2020.117305.
Carlson CR Jr, Uriu-Adams JY, Chambers CD, et al. Vitamin D Deficiency in Pregnant Ukrainian Women: Effects of Alcohol Consumption on Vitamin D Status. J Am Coll Nutr. 2017 Jan;36(1):44-56. doi:10.1080/07315724.2016.1174091.
Kaminskyi OV, Pankiv VI, Pankiv IV, Afanasyev DE. Vitamin D Content In Population Of Radiologically Contaminated Areas In Chernivtsi Oblast (pilot project). Probl Radiac Med Radiobiol. 2018 Dec;23:442-451. doi:10.33145/2304-8336-2018-23-442-451. (in Ukrainian).
Gennari L. Vitamin D deficiency is independently associated with COVID-19 severity and mortality. In: ASMBR 2020 Annual Meeting Virtual Event. 2020 Sep 11.
Liu N, Sun J, Wang X, Zhang T, Zhao M, Li H. Low vitamin D status is associated with coronavirus disease 2019 outcomes: a systematic review and meta-analysis. Int J Infect Dis. 2021 Jan 2;104:58-64. doi:10.1016/j.ijid.2020.12.077.
Darling AL, Blackbourn DJ, Ahmadi KR, Lanham-New SA. Very high prevalence of 25-hydroxyvitamin D deficiency in 6433 UK South Asian adults: analysis of the UK Biobank Cohort. Br J Nutr. 2021 Feb 28;125(4):448-459. doi:10.1017/S0007114520002779.
Altieri B, Muscogiuri G, Barrea L, et al. Does vitamin D play a role in autoimmune endocrine disorders? A proof of concept. Rev Endocr Metab Disord. 2017 Sep;18(3):335-346. doi:10.1007/s11154-016-9405-9.
Mazokopakis EE, Papadomanolaki MG, Tsekouras KC, Evangelopoulos AD, Kotsiris DA, Tzortzinis AA. Is vitamin D related to pathogenesis and treatment of Hashimoto's thyroiditis? Hell J Nucl Med. 2015 Sep-Dec;18(3):222-7.
Povorozniuk VV, Pankiv IV. Intercommunication between vitamin D deficiency and thyroid hypofunction. Clinical Endocrinology and Endocrine Surgery. 2014;3-4(48):12-16. doi:10.24026/1818-1384.3-4(48).2014.75353. (in Ukrainian).
Pankiv I. Impact of additional cholecalciferol supplementation on the level of thyroid peroxidase antibodies in patients with primary hypothyroidism. Bolʹ, sustavy, pozvonočnik. 2017;7(3):116-119. doi:10.22141/2224-1507.7.3.2017.116866. (in Ukrainian).
Niroomand M, Fotouhi A, Irannejad N, Hosseinpanah F. Does high-dose vitamin D supplementation impact insulin resistance and risk of development of diabetes in patients with pre-diabetes? A double-blind randomized clinical trial. Diabetes Res Clin Pract. 2019 Feb;148:1-9. doi:10.1016/j.diabres.2018.12.008.
Jetty V, Glueck CJ, Wang P, et al. Safety of 50,000-100,000 Units of Vitamin D3/Week in Vitamin D-Deficient, Hypercholesterolemic Patients with Reversible Statin Intolerance. N Am J Med Sci. 2016 Mar;8(3):156-62. doi:10.4103/1947-2714.179133.
Noe S, Heldwein S, Pascucchi R, et al. Cholecalciferol 20 000 IU Once Weekly in HIV-Positive Patients with Low Vitamin D Levels: Result from a Cohort Study. J Int Assoc Provid AIDS Care. 2017 Jul/Aug;16(4):315-320. doi:10.1177/2325957417702487.
Takács I, Tóth BE, Szekeres L, Szabó B, Bakos B, Lakatos P. Randomized clinical trial to comparing efficacy of daily, weekly and monthly administration of vitamin D3. Endocrine. 2017 Jan;55(1):60-65. doi:10.1007/s12020-016-1137-9.
Rothen JP, Rutishauser J, Walter PN, Hersberger KE, Arnet I. Oral intermittent vitamin D substitution: influence of pharmaceutical form and dosage frequency on medication adherence: a randomized clinical trial. BMC Pharmacol Toxicol. 2020 Jul 11;21(1):51. doi:10.1186/s40360-020-00430-5.
Cavalier E, Faché W, Souberbielle JC. A Randomised, Double-Blinded, Placebo-Controlled, Parallel Study of Vitamin D3 Supplementation with Different Schemes Based on Multiples of 25,000 IU Doses. Int J Endocrinol. 2013;2013:327265. doi:10.1155/2013/327265.
Nudy M, Krakowski G, Ghahramani M, Ruzieh M, Foy AJ. Vitamin D supplementation, cardiac events and stroke: A systematic review and meta-regression analysis. Int J Cardiol Heart Vasc. 2020 May 20;28:100537. doi:10.1016/j.ijcha.2020.100537.
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