Characteristics of cognitive function in patients with adult-onset diabetes mellitus type 2 depending on the presence of depressions

N.M. Zherdova

Abstract


Background. Patients with diabetes mellitus (DM) suffer comorbid depression 1.4–3 times more often than those without DM. According to the latest data, DM in the world is on the 8th place as a cause of disability in the population, while depressive disorders occupy the 4th position. Depression affects emotion, cognition, and behavior, which results in the patient’s failure to carry out adequate treatment of the disease as a consequence of decompensation. The aim of the study was to examine the relationship between cognitive status and the presence of depression in patients with adult-onset DM. Materials and methods. 81 patients with type 2 DM were examined, including 43 women and 38 men. Patients were divided into 2 groups, with and without depressive disorders. Assessment of depressive symptoms was conducted using questionnaires filled in by the patient himself, including: Centre for Epidemiologic Studies Depression Scale, Hospital Anxiety and Depression Scale. Results. According to the Centre for Epidemiologic Studies Depression Scale, the incidence of depressive disorders was 38.3 %. During examination of cognitive function, there was noted a significant decrease in performance of neuropsychological tests, namely clock drawing test and Frontal Assessment Battery (FAB)бы in patients with depressive disorders. In the study of the relationship of various factors, such as the duration of the disease, body mass index, systolic blood pressure, diastolic blood pressure, levels of total cholesterol, triglycerides, vibration sensitivity and the severity of depressive symptoms, no significant differences were found, while the level of glycated haemoglobin had a significant correlation with depression. Conclusions. Patients with depression had a significant decline of cognitive function according to the FAB, Mini-Mental State Examination and clock drawing test that determines the defeat of the frontal lobe of the brain. There was found a significant relationship between the level of glycated hemoglobin and the severity of depression. Thus, it is necessary to carry out screening for depressive disorders among patients with DM for the timely assistance and prevention of cognitive decline and disability in patients.


Keywords


diabetes mellitus; anxiety-depressive disorders; cognitive impairment; depression; memory

References


DeGroot M, Jacobson AM, Samson JA, Welch G. Glycemic control and major depression in patients with Type 1 and Type 2 diabetes mellitus. J Psychosom Res. 1999;46:425-435.

Andreoulakis Е, Hyphantis Т, Kandylis D, Iacovides A. Depression in diabetes mellitus: a comprehensive review. Hippokratia. 2012;16(3):205-214.

Lin EH, Von Korff MV. Mental disorders among persons with diabetes. Results from the World Mental Health Surveys. J Psychosom Res. 2008;65:571-580.

Fischer L, Skaff MM, Mullan JT, Areant P, Glasgow R, Masharani U. A longitudinal study of affective and anxiety disorders, depressive affect and diabetes distress in adults with type 2 diabetes. Diabet Med. 2008;25:1096-1101.

Egede LE, Ellis C. The effects of depression on metabolic control and quality of life in indigent patients with type 2 diabetes. Diabetes Technol. 2010;12:257-262.

Katon W, Russo J, Lin EH, Heckbert SR, Karter AJ, Ciechanowski P et al. Depression and diabetes: factors associated with major depression at five-year follow-up. Psychosomatics. 2009;50:570-579.

Papelbaum M, Moreira RO, Countinho W, Kupfer R, Zagury L, Freitas S et al. Depression, glycemic control and type 2 diabetes. Diabetol Metab Syndr. 2011;3:26-29.

Dirmaier J, Watzke B, Koch U, Schulz H, Lehnert H, Pieper L et al. Diabetes in primary care: prospective associations between depression, nonadherence and glycemic control. Psychother Psychosom. 2010;79:172-178.

Davoodi F, Etemad K, Taheri Tanjani P, Khodakarim S. The Relationship between Depression and Cognitive Impairment with Falls Leading to Fractures in Elderly. J Saf Promot Inj Prev. 2016;4(2):75-82.

National Institute of Health Metrics Evaluation Global Burden of Disease. 2015. Available from: http://vizhub.healthdata.org/gbd-compare/.

American Psychiatric Association, Task F. Diagnostic and statistical manual of mental disorders DSM-5. Fifth edition 2013. Available from: http://dsm.psychiatryonline.org.




DOI: https://doi.org/10.22141/2224-0721.13.1.2017.96756

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru