Selenium and autoimmune thyroid disorders

N.V. Pashkovska


Information about the importance of selenium for thyroid homeostasis, the role of selenium deficiency in the pathogenesis of autoimmune thyroid disorders and effectiveness of selenium-containing drugs in the treatment of thyreopathies with autoimmune origin is given in the lecture.


selenium; autoimmune thyreopathies; selenium-containing drugs


Goncharova ОА. Selenium and thyroid (review of literature and data of own researches). Endocrinologia. 2014;19(2):149-155 (Russian).

Paskkovska NV. Treatment of hypothyroidism according to the modern clinical guidelines. International Journal of Endocrinology. 2016;6(78):48-58 (Ukrainian). DOI: 10.22141/2224-0721.6.78.2016.81860.

Sen’kevich OA, Golubkina NA, Koval’skiy UG. Diagnostics of selenium sufficemcy and estimation of degree of its deficitiency. Dal’nevostochnyi meditsinskiy zhurnal. 2011;4:78-80 (Russian).

Chursina TY, Mikhalev RA. Little players of large orchestra, or as years to one hundred raise to us without old age. Therapia. Ukrainskiy medychnyi visnyk. 2015;2:55-58 (Russian).

Calissendorff J, Mikulski E, Larsen EH et al. A prospective investigation of Graves’ disease and selenium: thyroid hormones, auto-antibodies and self-rated symptoms. Eur Thyroid J. 2015;4(2):93-98.

Arrojo E, Drigo R, Bianco AC. Type 2 deiodinase at the crossroads of thyroid hormone action. Int J Biochem Cell Biol. 2011 Oct;43(10):1432-41. doi: 10.1016/j.biocel.2011.05.016.

Beckett GJ, Arthur JR. Selenium and endocrine systems. J Endocrinol. 2005;184(3):455-465.

Brigelius-Flohé R. The Evolving Versatility of Selenium in Biology. Antioxid Redox Signal. 2015;23(10):757-760.

Dharmasena A. Selenium supplementation in thyroid associated ophthalmopathy: an update. Int J Ophthalmol. 2014;7(2):365-375.

Demelash A, Karlsson JO, Nilsson M. Selenium has aprotective role in caspase-3-dependent apoptosis in duced by H2O2 in primary cultured pig thyrocytes. Eur J Endocrin. 2004;150:841-849. PMID: 15191356.

Drutel A, Franoise A, Philippe CD. Selenium and the thyroid gland more good news for clinicians. Clin Endocrinol. 2013;78(2):155-164.

Duntas LH, Benvenga S. Selenium: an element for life. Endocrine. 2015;48(3):756-775.

Duntas LH. The Role of Iodine and Selenium in Autoimmune Thyroiditis. Horm Metab Res. 2015 Sep;47(10):721-6. doi: 10.1055/s-0035-1559631.

Zimmermann MB, Adou P, Torresani T et al. Effect of oral iodized oil on thyroid size and thyroid hormone metabolism in children with concurrent selenium and iodine deficiency. European Journal of Clinical Nutrition. 2000;54:209-213.

Contempre B, Duale NL, Dumont JE еt al. Effect of selenium supplementation on thyroid hormone metabolism in an iodine and selenium deficient population. Clinical Endocrinology. 1992;36:579-583.

Duntas LH, Mantzou E, Koutras DA. Effects of a six month treatment with selenomethionine in patients with autoimmune thyroiditis. European Journal of Endocrinology. 2003;148:389-393.

Gärtner R, Gasnier BC. Selenium in the treatment of autoimmune thyroiditis.Biofactors. 2003;19:165-170.

Gislefoss R, Jellum E. The Janus serum bank and biomarkers of cancer. Norsk Epidemiologi. 2006;16(1):53-57.

Lacka K, Szeliga A. Significance of selenium in thyroid physiology and pathology. Pol Merkur. Lekarski. 2015;38(228):348-353.

Rasmussen LB, Schomburg L, Köhrle J et al. Selenium status, thyroid volume, and multiple nodule formation in an area with mild iodine deficiency. Eur J Endocrinol. 2011 Apr;164(4):585-90. doi: 10.1530/EJE-10-1026. Epub 2011 Jan 17.

Marcocci C, Kahaly GJ, Krassas GE. European Group on Graves’ Orbitopathy. Selenium and the course of mild Graves’ orbitopathy. N Engl J Med. 2011;364(20):1920-1931.

Osadtsiv OI, Kravchenko VI, Andrusyshyna IM. Selenium efficiency in prophylaxis and complex treatment of diffuse goiter. Lik Sprava. 2014;7-8:110-116.

Roman M, Jitaru P, Barbante C. Selenium biochemistry and its role for human health. Metallomics. 2014;6:25-54.

Russell B. Selenium stories. Nature Chemistry. 2011;3(7):570.

Samir M, el-Awady MY. Serum selenium levels in multinodular goiter. Clinical Otolaryngology and Allied Sciences. 1998;23:512-514.

Roy G, Mugesh G. Selenium analogues of antithyroid drugs-recent developments. Chemistry & Biodiversity. 2008;5:414-439.

Marcocci C, Kahaly GJ, Krassas GE et al. Selenium and the course of mild Graves’ orbitopathy. The New England Journal of Medicine. 2011;364:1920-1931.

Zuuren EJ, Albusta YA, Fedorowicz Z et al. Selenium Supplementation for Hashimoto’s Thyroiditis: Summary of a Cochrane Systematic Review. Eur Thyroid J. 2014;3(1):25-31.

Watt T, Cramon P, Bjorner JB et al. Selenium supplementation for patients with Graves' hyperthyroidism (the GRASS trial): study protocol for a randomized controlled trial. Trials. 2013 Apr 30;14:119. doi: 10.1186/1745-6215-14-119.

Wichman J, Winther KH, Bonnema SJ et al. Selenium Supplementation Significantly Reduces Thyroid Autoantibody Levels in Patients with Chronic Autoimmune Thyroiditis: A Systematic Review and Meta-Analysis. Thyroid. 2016;26(12):1681-1692.

Gartner R, Gasnier BCH, Dietrich JW et al. Selenium supplementation in patients with autoimmune thyroiditis decreases thyroid peroxidase antibodies concentrations. Journal of Clinical Endocrinology and Metabolism. 2002;87:1687-1691.

Toulis KA, Anastasilakis AD, Tzellos TG еt al. Selenium supplementation in the treatment of Hashimoto’s. Clinical Endocrinology. 2013;78:155-164.

Kohrle J, Jakob F, Contempre B. Selenium, thethyroid, and the endocrine system. Endocrine Reviews. 2005;26:944-984.

Hatfield DL, Berry MJ, Gladyshev VN. Selenium: Its Molecular Biology and Role in Human Health. Springer Science Business Media. 2012:598.

Wertenbruch T, Willenberg HS, Sagert C et al. Serum selenium levels in patients with remission and relapse of Graves’ disease. Medicinal Chemistry. 2007;3:281-284.

Sakız D, Kaya A, Kulaksizoglu M. Serum Selenium Levels in euthyroid nodular thyroid diseases. Biol Trace Elem Res. 2016;174(1):21-26.

Stagnaro-Green А, Pearce E. Thyroid disorders in pregnancy. Nature Reviews Endocrinology. 2012;8:650-658.

BacicVrca V, Skreb F, Cepelak I et al. Supplementation with antioxidants in the treatment of Graves’ disease: the effect on the extracellular antioxidative parameters. Acta Pharmaceutica. 2004;54:79-89.

Watt T, BueBjorner J, Cramon P et al. The chronic autoimmune thyroiditis quality of life selenium trial (CATALYST): study protocol for a randomized controlled trial. Trials. 2014;15(115). DOI: 10.1186/1745-6215-15-115. Available from:

Negro R, Greco G, Mangieri T et al. The influence of selenium supplementation on postpartum thyroid status in pregnant women with thyroid peroxidase autoantibodies. J Clin Endocrinol Metab. 2007;92(4):1263-1268.

Winther KH, Bonnema SJ, Cold F. Does selenium supplementation affect thyroid function? Results from a randomized, controlled, double-blinded trial in a Danish population. Eur J Endocrinol. 2015;172(6):657-667.



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