Influence of nutrient correction on adiponectin circulating level and cardiovascular risk factors in patients with type 2 diabetes mellitus and non-alcoholic fatty liver disease

I.P. Dunayeva

Abstract


Aim — to evaluate the influence of dietary recommendations on adiponectin circulating level and haemodynamic characteristics in patients with type 2 diabetes mellitus (DM) and non-alcoholic fatty liver disease. Materials and methods. 34 patients with type 2 DM and non-alcoholic fatty liver disease were examined (15 women and 19 men) with duration of disease of 10.37 ± 1.00 years. The average age of patients was 61.09 ± 1.76 years. Results. The article presents the results of the effect of standard treatment with inclusion of nutrient therapy in type 2 DM patients with non-alcoholic fatty liver disease on adiponectin circulating level and hemodynamics, echocardiographic characteristics and structural-functional condition of the vessels. A significant increase of adiponectin level was found. The greatest effect is defined in terms of normalization of the blood pressure. Then follow the impact on the left ventricular mass and then — on the normalization of the left ventricular cavity. Very low effect was found on the norma­lization of left ventricular systolic function (ejection fraction).Conclusions. The analysis of the dynamics of diastolic function indicators showed the increase of the early left ventricular filling velocity, the decrease in the late left ventricular filling velocity, as well as the growth of their relations. The analysis of the structural-functional condition of the vessels showed the decrease of pulse wave velocity in the carotid artery and abdominal aorta, the growth of the endothelium-dependent vasodilation degree in the absence of significant changes in the thickness of the intima-media.

Keywords


type 2 diabetes mellitus; nutrient correction; myocardial remodeling; nonalcoholic fatty liver disease; adiponectin

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DOI: https://doi.org/10.22141/2224-0721.13.1.2017.96751

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