Changes of Cytokine Level in Patients with Hypertension and Obesity, Depending on the Duration of the Disease

V.A. Kapustnik, I.F. Kostyuk, В.О. Shelest, Кovalyova J.O.

Abstract


Interleukins (IL) 2, 6, 10, and C-reactive protein are crucial in arterial hypertension with obesity. Background. To identify the characteristics of inflammatory markers in patients with arterial hypertension and obesity, in accordance with the disease duration. Materials and Methods. The study involved 52 patients with stage II hypertension and obesity, divided in three groups according to the disease duration. In the first group consisted of 19 patients disease duration was 5 years, in the second (18 patients) — 6–10 years, and in the third one (15 patients) — more than 11 years. The serum levels of inflammatory markers were determined by ELISA. Results. When disease duration is 6–10 years, the IL‑6 level is increased slightly compared to the first group, and then decreased. The content of IL‑2 was increased in the first group by 3.74 times, and further decreased by 3.15 times and 3.04 times, respectively, compared to the controls. Levels of IL‑10 and C-reactive protein have the same tendency, as IL‑6. Conclusions. It was found that levels of interleukin 2, 6, 10, and C-reactive protein are significantly increased in patients with hypertension and obesity (greater levels of pro-inflammatory cytokines than the anti-inflammatory). Lengthening the duration of illness leads to less expressive inflammation that may indicate deeper immunological disorders. Initially increased blood concentration of cytokines and C-reactive protein became significantly reduced under standard therapy, but not significantly different from the controls, except the level of IL‑2.


Keywords


arterial hypertension; obesity; interleukins; C-reactive protein; treatment

References


Druzhilov MA, Druzhilova ОY, Beteleva YE, Kuznetsova ТY. Obesity as cardiovascular risk factor: accent on quality and functional activity of fatty tissue. Rossiyskiy kardiologicheskiy zhurnal. 2015;4(120):111-117. DOI: 10.15829/1560-4071-2015-04-111-117 (Russian)

Bilovol OM, Kovaliova OM, Popova SS, Tveretinov OB. Obesity in practice of cardiologist and endocrinologist. Теrnopil: Ukrmedknyga, 2009; 301 s. (Ukrainian)

Gusiev EY, Chereshniov VA. System inflammation: theoretical and methodological description of model of pathological process. Part 4. Dynamics of process. Patologicheskaya fiziologia i eksperimentalnaya terapiya. 2014;58(4):4-16. (Russian)

Zhang C. The role of inflammatory cytokines in endothelial dysfunction. Basic Res. Cardiol. 2008;103(5):398-406. DOI:10.1007/s00395-008-0733-0

Simonenko VB, Medvedev IN, Nosova TY. Aggregating function of thrombocytes at persons with arterial hypertension and abdominal obesity. Кlinicheskaya meditsina. 2008;5:22-24. (Russian)

Helmersson-Karlqvist J, Björklund-Bodegård K, Larsson A, Basu S. 24-Hour ambulatory blood pressure associates inversely with prostaglandin F (2α), interleukin-6 and F(2)-isoprostane formation in a Swedish population of older men. Int. J. Clin. Exp. Med. 2012;5(2):145-53. PMID:22567175; PMCID:PMC3342711

Levi M, van der Poll T. Inflammation and coagulation. Crit. Care Med. 2010;38:26-34. PMID:20083910; DOI:10.1097/CCM.0b013e3181c98d21

Tuzankina IA. To the question about diagnostics of immunopathology. Меditsinskaya immunologia. 2010;6:485-496. DOI: http://dx.doi.org/10.15789/1563-0625-2010-6-485-496 (Russian)

Beghdali W, Madjene LC, Benhamou M. Mast cell as cellular sensors in inflammation and immunity. Front. Immunol. 2011;2:37-52. PMCID: PMC3342044; doi: 10.3389/fimmu.2011.00037

George Cr. From Fahrenheit to cytokines: fever, inflammation and the kidney. J. Nephrol. 2006;19(10):88-97. PMID:16874719

Ovsiannikov VG, Boychenko AE, Blikian MV. С-reactive protein in patients with somatic pain. Tsitokiny i vospaleniye. 2013;1:22-25. (Russian)

Radtke S, Waller S, Yang X. Cross-regulation of cytokine signalling: pro-inflammatory cytokines restrict IL-6 signalling through receptor internalisation and degradation. J. Cell. Sci. 2010;13(6):947-959. doi: 10.1242/jcs.065326.

Kishimoto T. Interleukin-6: discovery of a pleiotropic cytokine. Arthritis Res. Ther. 2006;8(2):2-14. PMID: 16899106; PMCID: PMC3226075; DOI:10.1186/ar1916

Ketlinskiy SA, Simbirtsev AS. Cytokines. SPb.:Foliant, 2008;408 s. (Russian)

Serebrennikova SN, Seminskiy IZ. A role of cytokines in an inflammatory process. Sibirskiy meditsinskiy zhurnal. 2008;6:5-8. (Russian)

Chereshniova MV, Chereshniov VA. Immune and pathological mechanisms of local inflammation. Меditsinskaya immunologiy. 2011;6:557-568. (Russian)

Маrkelova EV, Kostiushko AV, Krasnikov VE. Nosotropic role of violations in the system of cytokines at infectiously-inflammatory diseases. Tihooreanskiy meditsinskiy zhurnal. 2008;3:24-29. (Russian)

Мukhundinova FI, Mustafin IG, Hafizianova RH. Cytokines of lymph and blood at the fever of different degree of expressed. Bulleten’ eksperimental’noy biologii i meditsiny. 2012;153(4):438-440. (Russian)

Theoharides TC, Alysandratos KD, Angelidou A. Mast cells and inflammation. Biochim. Biophys. Acta. 2012;1822(1):21-33. PMID: 21185371; PMCID: PMC3318920; DOI:10.1016/j.bbadis.2010.12.014

Sandgren NC, Zhu W, Yuhanna IS. Coupling of FcγRI to FcγRIIB by Src Kinase Mediates C-reactive Protein Impairment of Endothelial Function. Circ. Res. 2011;109(10):1132-1140. doi: 10.1161/CIRCRESAHA.111.254573




DOI: https://doi.org/10.22141/2224-0721.8.80.2016.89537

Refbacks

  • There are currently no refbacks.


Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2017

 

 Яндекс.МетрикаSeo анализ сайта Рейтинг@Mail.ru