In Tune with the World Trends: Clinical Aspects of Liraglutide Use in Combination with Insulin in Patients with Diabetes Mellitus (Literature Review and Clinical Observations)

O.V. Korpacheva-Zinych, N.M. Kushnariova, A.V. Kovalchuk, O.V. Prybila, K.O. Shyshkan-Shyshova, N.M. Huryna, V.V. Korpachev


There is presented a review of the literature on the treatment of diabetes mellitus type 1 and 2 based on incretin effect, the mechanisms of action, advantages and limitations of a new class of antidiabetic drugs — glucagon-like peptide-1 receptor agonists, their clinical use in combination with insulin, allowing to neutralize the negative effects of the latter. Liraglutide successful clinical use is described in patients suffering from diabetes mellitus type 2 in cases of ineffectively controlled fasting glucose, in the absence of glycemia compensation with high doses of insulin and metformin, as well as in cardiorenal syndrome.


diabetes mellitus; incretin mimetics; insulin therapy; obesity; review; glucagon-like peptide-1


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