Vitamin D Deficiency and Vascular Lesions in Diabetes Mellitus Type 2

A.S. Yefimov, L.M. Mikhalchuk

Abstract


Background. For today low level of vitamin D in the blood serum in patients with diabetes mellitus (DM) type 2 is considered as a prognostic index of further development of macrovascular lesions, herewith connection of vitamin D deficiency with capillary complications is studied not enough.
The objective of the study — to establish provision of the organism of patients with DM type 2 with vitamin D, and also the correlation of vitamin D deficiency with macro- and microvascular diabetic complications.
Materials and methods of study: 44 patients with type 2 DM were under observation. Examination of vitamin D level (Vit. D total) and parathyroid hormone of blood serum was carried out using chemiluminescent method on Elecsys 2010 analyzer (Roche Diagnostics, Germany) with cobas test systems.
Results: in all patients with type 2 DM we have detected vitamin D deficiency (mean value of 20.29 ± 1.35 nM/L), changes in parathyroid hormone content were not revealed. We noted significantly lower levels of vitamin D sufficiency of the body in patients with proliferative diabetic retinopathy compared with patients who did not reveal diabetic retinopathy.
Conclusions: all patients who suffer from type 2 DM revealed vitamin D deficiency, and 80 % of them had severe deficiency. A trend towards higher incidence of macrovascular lesions of the lower extremities in vitamin D deficiency has been detected. Vitamin D deficiency contributes to DM decompensation and as a consequence, the worsening of vascular lesions of the retina.


Keywords


diabetes mellitus type 2; obesity; vitamin D deficiency; glycated hemoglobin; DM complications

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DOI: https://doi.org/10.22141/2224-0721.5.53.2013.84471

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