Functional Foods in Complex Treatment of Patients with Metabolic Syndrome

V.I. Pankiv, S.M. Yurchak

Abstract


Functional foods are intended for a systematic daily consumption and have a regulating effect on physiological functions, biochemical reactions and psychosocial behavior due to the normalization of microecological status.
Objective of the study — improving the efficiency of complex treatment of patients with metabolic syndrome by the use of dietary supplements BioSESS.
Materials and Methods. 26 patients with metabolic syndrome (I stage obesity, arterial hypertension, lipid disorders, impaired glucose tolerance) were examined. BioSЕSS was administered for 4 capsules 2 times a day during 10 days, in 20 days after completion of the first course the second one was administered in a similar way. Comparison group consisted of 14 patients with metabolic syndrome, who hadn’t receive BioSESS in complex treatment.
Results of the Study. Significant and statistically reliable decrease of insulin resistance in peripheral tissues was noted. НОМА-IR index decreased significantly — from 6.58 ± 0.92 to 3.44 ± 0.86. There is observed significant reduction in total cholesterol content by 13.1 % from initial data — 6.18 ± 0.24 mmol/l to 5.46 ± 0.22 mmol/l (р < 0.05), very low density lipoproteins — by 36.2 %, from 0.79 ± 0.07 mmol/l to 0.58 ± 0.06 mmol/l (р < 0.05), low density lipoproteins — by 5.9 %, from 3.98 ± 0.16 mmol/l to 3.56 ±
± 0.18 mmol/l (p < 0.05), triglycerides — by 37.2 %, from 1.77 ±
± 0.19 mmol/l to 1.29 ± 0.14 mmol/l (р < 0.05). The combined therapy assisted more significant decrease in C-reactive protein (СRP) level (from 6.91± 0.66 mg/dl to 4.83 ± 0.58 mg/dl) compared to control group (by 31.2 and 23.1 %, respectively, p < 0.05).
Conclusions. Application of BioSESS in complex therapy of patients with metabolic syndrome for certain improves the indexes of lipid metabolism, reduces hyperinsulinemia and concomitant insulin resistance. The use of BioSESS in complex therapy of patients with metabolic syndrome promotes the decline of blood pressure level in day time, improvement of diastolic function of myocardium. In patients with metabolic syndrome BioSESS has useful pleiotropic effects that are manifested in the significant decrease of CRP levels in the blood by 31.2 % (p < 0.05).


Keywords


metabolic syndrome; functional foods; lipid metabolism; insulin resistance

References


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DOI: https://doi.org/10.22141/2224-0721.3.51.2013.84330

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