Relation between Hormonal Disorders and Components of Metabolic Syndrome in Patients with Primary Hypothyroidism

Main Article Content

Т.Yu. Yuzvenko


During the last decade plenty of the researches dedicated to the problem of hypothyroidism were published, that radically changed views to the value of thyroid pathology on the whole. Neurohumoral changes are considered as a nosotropic factor of hypothyroidism development in persons with metabolic syndrome (MS). Aim of the research is to study the features of hormonal disorders and their correlation with the components of metabolic syndrome in patients with primary hypothyroidism. Materials and methods. The study involved 80 patients with primary hypothyroidism: 61 had metabolic syndrome and 19 did not have metabolic syndrome. Results. Statistically significant increased levels of leptin, insulin, cortisol, C-peptide were revealed in patients with hypothyroidism and metabolic syndrome while the most marked changes were found in patients with multiple metabolic abnormalities. Conclusions. The interrelations between hyperleptinemia and fasting glucose, glycated hemoglobin, insulin levels, thyroid-stimulating hormone, index HOMA were determined indicating the modulating role of chronic hyperglycemia, hormonal disorders and insulin resistance in the expression and realization of the biological action of leptin in patients with hypothyroidism and metabolic syndrome.

Article Details

How to Cite
Yuzvenko Т. “Relation Between Hormonal Disorders and Components of Metabolic Syndrome in Patients With Primary Hypothyroidism”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 6.78, Nov. 2016, pp. 66-70, doi:10.22141/2224-0721.6.78.2016.81862.
Clinical Thyroidology


Vanderpump MPJ. The epidemiology of thyroid disease. Br Med Bull. 2011;99(1);39-51.doi: 10.1093/bmb/ldr030

Mitchenko OI. Vid imeni Robochoi grupy z metabolichnoho syndromu, preddiabetu i sertsevo-sudynnykh zahvoriuvan Ukrainskoi asotsiatsii kardiolohiv i Ukrainskoi asotsiatsii endokrynolohiv [On behalf of the Working Group of the metabolic syndrome, prediabetes and cardiovascular diseases Ukrainian Heart Association and Ukrainian Association of Endocrinologists]. Ukrainskyi medychnyi chasopys. 2007;2(58),III/IV;4–13. [Ukrainian].

Korpacheva-Zinych OV. Statevi osoblyvosti vzaiemozviazku klasteriv metabolichnoho syndromu z pokaznykamy androheniv nadnyrkovykh zaloz u khvorykh na tsukrovyi diabet 2-ho typu pokhyloho viku [Gender interconnection features of the metabolic syndrome cluster with indicators of adrenal androgens in elderly patients with diabetes mellitus type 2]. Ukrainskyi medychnyi chasopys. 2009;1(69),II;66–71. [Ukrainian].

Rahmani F, Hojjati Z, Soltani B. Leptin, heart disease and exercise. World Journal of Sport Sciences. 2009;2(1):13–20.

Baxter JD, Webb P. Thyroid hormone mimetics: potential applications in atherosclerosis, obesity and type 2 diabetes. Nature Reviews Drug Discovery. 2009;8(4):308-320.

Hage M, Zantout MS, Azar ST. Thyroid disorders and diabetes mellitus. Journal of Thyroid Research. 2011. –

Papazafiropoulou A. Prevalence of thyroid dysfunction among greek Type 2 diabetic patients attending an outpatient clinic. Journal of Clinical Medicine Research. 2010;2(2):75-78.

Wang C. The Relationship between type 2 diabetes mellitus and related thyroid diseases // J Diabetes Res. – 2013. doi:10.1155/2013/390534 PMCID: PMC3647563.

Ashizawa K, Imaizumi M, Usa T, Tominaga T. Metabolic cardiovascular risk factors and their clustering in subclinical hypothyroidism. Clin. Endocrinol. 2010;72(5):698–695.

Boekholdt MS, Titan SM, Wersinga WM, Chatterjee K. Initial thyroid status and cardiovascular risk factors: the EPIC-Norfolk prospective population study. Clin. Endocrinol. 2010;72(3):404–410.

Riis AL, Gravholt CH, Djurhuus CB. Elevated regional lipolysis in hyperthyroidism. Clin. Endocrinol. 2010;74(6):769–775.

Wolk R. Leptin level independently predicts CVD risk. J. Am. Coll. Cardiol. 2004;44:1819–1824.

Halle M, Persson PB. Role of leptin and leptin receptor in inflammation. Am J Physiol Regul Integr Comp Physiol. 2003;284(3):760–762.

Wolk R. Leptin level independently predicts CVD risk. J. Am. Coll. Cardiol. 2004;44:1819–1824.