Influence of Vitamin D on the Indexes of Type 2 Diabetes Mellitus Compensation
Background. Diabetes mellitus (DM) results in violation of all types of metabolism (first of all carbohydrate one), lesion of vessels, nerves, different organs and tissues. However, the influence of DM on the trace elements level is not well studied yet. In spite of a good arsenal of medicaments, attaining DM compensation is succeeded less than in 30 % patients. For this reason the search of new ways to improve carbohydrate metabolism remains actual. Objective: to reveal the deficiency of 25-hydroxyvitamin D and its correlation with carbohydrate metabolism. Materials and methods. Thirty-five patients with type 2 DM were examined, aged 55–74 years old, duration of disease was 2–4 years. The control group included 35 practically healthy people of the same age and sex. Serum levels of 25-hydroxyvitamin D were tested using radioimmunoassay. Level of glycated hemoglobin was tested using liquid chromatography method. Results. In 37.1 % patients with type 2 DM deficit of vitamin D is educed. Thus in 61.5 % among them DM compensation was satisfactory (HbA1с level was 7.5–8.5 %), and in 38.5 % unsatisfactory (HbA1с level > 8.5 %). Negative correlation is set between the increase of HbA1с level and decline of 25(OH)D (r = –0.39, p < 0.05). Conclusions. The significant improvement of the state of type 2 diabetes mellitus compensation is set after the drug correction of vitamin D level.
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Kharroubi AT, Darwish HM. Diabetes mellitus: The epidemic of the century. World J Diabetes. 2015;25(6):850-867. doi:10.4239/wjd.v6.i6.850
Pankiv VI. Diabetes mellitus: definition, epidemiology, risk factors. International Journal of Endocrinology. 2013;7(55):95-104. (Ukrainian)
Yefimov AS, Мykhalchuk LM. Vitamin D deficiency and vascular disorders in patients with type 2 diabetes mellitus. International Journal of Endocrinology. 2013;5(53):10-13. (Ukrainian)
Коmisarenko YI. Vitamin D deficiency and its important in development of metabolism disorders in patients with diabetes mellitus. Clinical Endocrinology and Endocrine Surgery. 2013;3:69-74.
Pittas A, Lau J, Hu F, Dawson-Hughes B. The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis. J Clin Endocrinol Metab. 2007;92:2017-2029.
Pittas A, Nelson J, Mitri J. Plasma 25-hydroxyvitamin D and progression to diabetes in patients at risk for diabetes: an ancillary analysis in the Diabetes Prevention Program. Diabetes Care. 2012;35:565-573.
Lau S, Gunton J, Athayde N. Serum 25-hydroxyvitamin D and glycated haemoglobin levels in women with gestational diabetes mellitus. Med J Aust. 2011;194:334-337.
Alzaim M, Wood R. Vitamin D and gestational diabetes mellitus. Nutr Rev. 2013;71:158-167.
Kienreich K, Tomaschitz A, Verheyen N. et al. Vitamin D and cardiovascular disease. Nutrients. 2013;5(8):3005-3021.
Povorozniuk VV, Balatska NI, Muts VY. Vitamin D deficiency and insufficiency in Ukrainian population. Bol, sustavy, pozvonochnik. 2011;4:5-13.
Holick MF, Binkley NC, Bischoff-Ferrari HA. Endocrine Society: Evaluation, treatment, and prevention of vitamin D deficiency: an Endocrine Society clinical practice guideline. J. Clin. Endocrinol. Metab. 2011;96:1911-1930.
Schöttker B, Jorde R, Peasey A. Vitamin D and mortality: meta-analysis of individual participant data from a large consortium of cohort studies from Europe and the United States. BMJ. 2014;348. g3656. doi: 10.1136/bmj.g3656.
Povorozniuk VV, Reznichenko NA, Mailian EA. Vitamin D effects. Bol, sustavy, pozvonochnik. 2014;1-2:19-25.
O’Donnell S, Moher D, Thomas K. Systematic review of the benefits and harms of calcitriol and alfacalcidol for fractures and falls. J. Bone Miner. Metab. 2008;26(6):P.531-542.
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