Features of Oxidative Stress Formation in Patients with Type 2 Diabetes Mellitus Depending on the Disease Duration and Gender
Background. The incidence of type 2 diabetes is increasing in Ukraine and worldwide. The severity of this disease is determined by the number of complications, with lipid peroxidation (LPO) underlying. The aim of the study was to study the intensification of LPO and antioxidant systems (AOS) in 88 patients with type 2 diabetes mellitus (T2DM) and 50 people without the disease, depending on the duration of the illness and gander. Results. Our data indicate that the maximum intensification of LPO (blood levels of conjugated dienes and malondialdehyde) occurs within the first 5 years after diagnosis of T2DM. AOS activity (blood activity of superoxide dismutase and catalase and alfa-tocopherol blood level) reaches maximum values within the first 5 years of disease, and in 5–10 and more than 10 years significantly reduced at rather high intensity of LPO. Conclusions. Women with disease duration more than 10 years had significant reduction in the formation of malondialdehyde as compared to men, while dynamics of AOC activity did not significantly differ depending on the gender.
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Global status report on noncommunicable diseases 2014. Geneva, World Health Organization, 2014. URL: http://apps.who.int/iris/bitstream/10665/148114/1/9789241564854_eng.pdf
Pankiv VI. Improvement of health care to the patients with diabetes mellitus in ambulatory terms (pharmaco-epidemiological approach). Zdorovia Ukrainy ХХІ storichya. 2015;1:23-24. (Ukrainian)
Sokolova LK. Type 2 diabetes mellitus. Role of general physician. Ukrainskiy medychnyi chasopys. 2012;1(87):70-73. (Russian)
Popova TN. Intensity of free-radical processes in the liver of rats with type diabetes mellitus 2 types and introduction of epifamine. Eksperimentalnyje statti. 2013;4(19):129-134. (Russian)
Ishonina OG. Comparative characteristics of antioxidant status in women with diabetes type 2 of different age groups. Adv. Gerontol. 2011;24(4):645-649.
Bardymova TP. Lipid peroxidation, antioxidant system in patients with type 2 diabetes mellitus. Bulleten VSNC SO RАМN. 2005;6(44):50-54. (Russian)
Sorokina YA. Coefficients of oxidizing stress as method of personification of pharmacotherapy in the debut of type 2 diabetes mellitus. Universum: Meditsina i farmakologia. 2015;1(14): URL: http://7universum.com/ru/med/archive/item/1868 (Russian)
Balabolkin MI. Treatment of diabetes mellitus and its complications. М.: Meditsina, 2005:325.(Russian)
Balabolkin MI. Role of proteins glycating, oxidizing stress in pathogenesis of vascular complications at diabetes mellitus. Saharnyi diabet.2002;4:5-16. (Russian)
Zanozina ОV, Sorokina YA, Borovkov NN, Shcherbatiuk TG. "Vicious circle" of intercommunication of lipid peroxidation and oxidizing modification of proteins in patients with type 2 diabetes mellitus. Meditsinskiy almanakh. 2013;6:167-170. (Russian)
Lankin VZ, Tihaze AK, Kumskova EM. Features of low-density lipoproteis modification in development of atherosclerosis and type 2 diabetes mellitus. Kardiologicheskiy vestnik. 2008;3(1):60-67. (Russian)
Zanozina OV. A role of oxidative stress in development and progression of late complications of type 2 diabetes mellitus. Possibilities of antioxidant therapy. International Journal of Endocrinology. 2010;7(31):127-136. (Russian)
Tappia PS, Dent MR, Dhalla NS. Oxidative stress and redox regulation of phospholipase D in myocardial disease./ Free Radic. Biol. Med. 2006;41:349-361.
Gavrilov VB, Mishkorudnaya MI. Spectrophotometry determination of maintenance of hydroperoxides of lipids in pblood plasma. Laboratornoe delo. 1983;3:33-36. (Russian)
Goncherenko MS, Latinova AM. Method of estimation of lipid peroxidation. Laboratornoe delo. 1985;1:60-61. (Russian)
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