Features of Oxidative Stress Formation in Patients with Type 2 Diabetes Mellitus Depending on the Disease Duration and Gender

V.Ya. Mokrii, S.V. Ziablytsev, M.V. Cryshtal


Background. The incidence of type 2 diabetes is increasing in Ukraine and worldwide. The severity of this disease is determined by the number of complications, with lipid peroxidation (LPO) underlying. The aim of the study was to study the intensification of LPO and antioxidant systems (AOS) in 88 patients with type 2 diabetes mellitus (T2DM) and 50 people without the disease, depending on the duration of the illness and gander. Results. Our data indicate that the maximum intensification of LPO (blood levels of conjugated dienes and malondialdehyde) occurs within the first 5 years after diagnosis of T2DM. AOS activity (blood activity of superoxide dismutase and catalase and alfa-tocopherol blood level) reaches maximum values within the first 5 years of disease, and in 5–10 and more than 10 years significantly reduced at rather high intensity of LPO. Conclusions. Women with disease duration more than 10 years had significant reduction in the formation of malondialdehyde as compared to men, while dynamics of AOC activity did not significantly differ depending on the gender.


type 2 diabetes mellitus; lipid peroxidation; disease duration; gender


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DOI: https://doi.org/10.22141/2224-0721.5.77.2016.78757


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