The Role of Lipidogram Parameters during Pregnancy in the Prediction of Preeclampsia Development

I.B. Ventskovskaya, А.V. Аksionova, Т.Y. Yuzvenko

Abstract


Aim of investigation. To study the correlation between lipid metabolism during pregnancy and the risk of preeclampsia (PE). Material and methods. We have studied parameters of lipid metabolism in the blood serum of 267 pregnant women with the help of diagnostic kits. Blood sampling was carried out in I and II gestation trimesters. Total cholesterol (TC) and triglycerides (TG) were determined by colorimetric, enzymatic methods; high density lipoproteins (HDL) — with homogeneous method, low density lipoproteins (LDL) — with the direct method. Very low density lipoproteins (VLDL) concentration was calculated from the Friedwald equation: VLDL = TG / 2.2. Depending on the clinical picture of PE, 43 pregnant women were divided into groups with mild and moderate-to-severe courses of the disease. Results. Among women with PE, we observed significant changes of the lipid profile parameters in the II trimester. These women had elevated TG levels in the blood serum: I group — 1.73 ± 0.14 mM/l, II group — 1.86 ± 0.18 mM/l as compared to the group III (controls) — 1.32 ± 0.29 mM/l; decreased HDL indices: I group — 0.79 ± 0.19 mM/l; group II — 0.64 ± 0.04 mM/l in comparison with the control group — 1.17 ± 0.12 mM/l and increased VLDL — 0.78 ± 0.09 mM/l for group I, 0.90 ± 0.06 mM/l in women of group II unlike group III — 0.60 ± 0.16 mM/l. TC and LDL levels among patients with PE did not differ from pregnant women in the control group. Conclusions. It was demonstrated the existence of an imbalance in the synthesis of lipoproteins in women, whose pregnancies were complicated by development of PE that manifested by hypertriglyceridemia with predominance of atherogenic fractions. It was found that the investigation of the parameters of lipid profile in the II trimester of pregnancy allows us to predict the risk of PE and its long-term cardiovascular and metabolic consequences.


Keywords


preeclampsia; lipid pattern; atherogenic dysfunction

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DOI: https://doi.org/10.22141/2224-0721.5.77.2016.78754

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