DOI: https://doi.org/10.22141/2224-0721.8.64.2014.77867

Impact of Gender and Age Factors on the Correlation of Pituitary-Thyroid Hormones in Patients with Autoimmune Thyroiditis

O.A. Goncharova

Abstract


In 292 patients with autoimmune thyroiditis, indicators of thyroid homeostasis were studied by levels of thyroid stimulating hormone (TSH), T3, T4, FT4, as well as their ratio in groups of men and women under the age of 50 years and 50 years and older. It was found that correlations between hormones within the pituitary-thyroid axis have gender and age peculiarities. In men with age there is a significant increase in the ratio of TSH/T4 and TSH/T3, which may indicate a decrease in the thyrotroph sensitivity. Women found to have decreased levels of active forms of thyroid hormones (T3 and FT4) with age as evidenced by an increase in the ratio of T4/T3 and T4/FT4.


Keywords


thyroid homeostasis; gender and age characteristics

References


Паньків В.І. Практична тиреоїдологія [Текст] / В.І. Паньків. — Донецьк: Видавець О.Ю. Заславський, 2011. — 224 с.

Балаболкин М.И., Клебанова Е.М., Креминская В.М. Фундаментальная и клиническая тиреоидология: Учеб. пособие. — М.: Медицина, 2007. — 816 с.

Garber J.R. Clinical practice guidelines for hypothyroidism in adults: cosponsored by the American Association of Clinical Endocrinologists and the American Thyroid Association [Text] / J.R. Garber, R.H. Cobin, H. Gharib et al. // Thyroid. — 2012. — Vol. 22(12). — P. 1200-1235.

Wiersinga W.M. Guidelines: the use of L-T4 + L-T3 in the treatment of hypothyroidism [Text] / W.M. Wiersinga, L. Duntas, V. Fadeyever et al. // Eur. Thyroid J. — 2012. — Vol. 1. — P. 55-71.

Centanni M. Thyroxine treatment: towards an individually tailored dose [Text] / M. Centanni, A. Franchi, M.G. Santaguda et al. // Recenti Progr. Med. — 2007. — Vol. 98(9). — P. 445-451.

Panicker V. Common variation in the DIO2 gene predicts baseline psychological well-being and response to combination thyroxine plus triiodthyronine therapy in hypothyroid patients [Text] / V. Panicker, P. Saravanan, B. Vaidya et al. // J. Clin. Endocrinol. Metab. — 2009. — Vol. 94(5). — P. 1623-1629.

Persani L. What ATA-ETA guidelines indicate on T3/N4 treatment [Text] / L. Persani // News for hypothyroidism. II Forum of Endocrinology, Gubbio, 27–29 Sept. 2013. — P. 28-32.

Татарчук Т.Ф. Эндокринная гинекология (клинические очерки) [Текст]: В 2 ч. — Ч. 1 / Т.Ф. Татарчук, Я.П. Сольский. — К.: Заповіт, 2003. — 300 с.

Фролькис В.В. Старение и увеличение продолжительности жизни [Текст] / В.В. Фролькис. — Л.: Наука, 1988. — 239 с.

Безруков В.В. Эмоциональные зоны гипоталамуса: возможные механизмы влияния на продолжительность жизни [Текст] / В.В. Безруков, Т.А. Дубилей, Ю.Е. Рушкевич // Українська школа ендокринології: матеріали 56-ї наук.-практ. конф. з міжнар. участю, Харків, 17–18 травня 2012 р. — Харків, 2012. — С. 5-21.

Каркушко О.В. Особенности развития сахарного диабета 2 типа в пожилом возрасте [Текст] / О.В. Каркушко, В.Б. Шатило, В.П. Чижова // Українська школа ендокринології: матеріали 56-ї наук.-практ. конф. з міжнар. участю, Харків,17–18 травня 2012 р. — Харків, 2012. — С. 96-116.






Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.

 

© "Publishing House "Zaslavsky", 1997-2019

 

   Seo анализ сайта