The Meaning of Using «The Quality of Life Assessment of Growth Hormone Deficiency in Adults» Questionnaire in Patients with Non-Functional Pituitary Adenomas and Various Tumors of Chiasmosellar Area in Pre- and Postoperative Period

Main Article Content

Yu.M. Urmanova
M.Yu. Shakirova
D.A. Aliieva

Abstract

The authors have examined 136 patients with growth hormone deficiency (GHD) of various origins (pituitary tumors and ischemic heart disease — comparison group). The investigation of the quality of life on the basis of GHD questionnaire «Quality of Life Assessment of Growth Hormone Deficiency in Adults» (QoL-AGHDA) in 136 patients showed, that in all groups the average score was higher than normal one (normal < 11), and most significantly it was observed in patients of first, third and fourth groups and second subgroup of the fifth group. Reliable correlation between low basal levels of somatotropic hormone (STH), insulin-like growth factor-1 (IGF-1) of blood plasma and average score by GHD questionnaire QoL-AGHDA was found in the first, second, third, and fourth groups of the second subgroup of the fifth group of patients, that confirms high efficacy of using GHD questionnaire QoL-AGHDA in patients with GHD of various origins. 36 patients in 3 months after transnasal hypophysectomy reported reliable increase in the average score by GHD questionnaire on the background of decreased levels of STH and IGF-1. This shows that in the early postoperative period in patients the severity of hypopituitarism increases and the question of the prescription of hormone replacement therapy arises.

Article Details

How to Cite
Urmanova, Y., M. Shakirova, and D. Aliieva. “The Meaning of Using «The Quality of Life Assessment of Growth Hormone Deficiency in Adults» Questionnaire in Patients With Non-Functional Pituitary Adenomas and Various Tumors of Chiasmosellar Area in Pre- and Postoperative Period”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 7.63, Dec. 2014, pp. 118-24, doi:10.22141/2224-0721.7.63.2014.77209.
Section
Original Researches
Author Biographies

Yu.M. Urmanova, Republican Specialized Scientific and Practical Medical Centre of Endocrinology of Ministry of Healthcare of the Republic of Uzbekistan; Tashkent Pediatric Medical Institute

Department of Endocrinology, Pediatric Endocrinology

M.Yu. Shakirova, Republican Specialized Scientific and Practical Medical Centre of Endocrinology of Ministry of Healthcare of the Republic of Uzbekistan; Tashkent Pediatric Medical Institute

Department of Endocrinology, Pediatric Endocrinology

D.A. Aliieva, Republican Specialized Scientific and Practical Medical Centre of Endocrinology of Ministry of Healthcare of the Republic of Uzbekistan; Tashkent Pediatric Medical Institute

Department of Endocrinology, Pediatric Endocrinology

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