DOI: https://doi.org/10.22141/2224-0721.7.63.2014.77122

Associations between Mycoplasma and Components of Immune Response in Women with Autoimmune Thyroiditis

O.A. Honcharova

Abstract


There was investigated immunoglobulin G (IgG) to the mycoplasma (Mp) in the blood serum of women with autoimmune thyroiditis (AIT) of reproductive age and in postmenopausal periods. A control group consisted of women of similar periods without thyroid pathology. The presence of AIT was found not to be associated with increased IgG level to Mp and age factor in women. At the same time, the activity of mycoplasma infection in postmenopausal women increases both in women with AIT, and in the control group, but in women without thyroid pathology it occurs significantly more intensive (4.4-fold compared with women in reproductive period, and in AIT women — on 13.5 %). In women with AIT reliable associative links between IgG to MP and CD3, CD4, CD8, CD16 levels were not revealed. At the same time in a reproductive period there is a significant positive correlation with CD20 and negative one with CD95 (marker of Fas-mediated apoptosis), and in postmenopausal women — with a direct indicator of humoral immunity — antibodies to TG.


Keywords


mycoplasma; immunoglobulin G; autoimmune thyroiditis; postmenopausal and reproductive periods

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