Dynamics of Endothelial Function Impairment in Patients with Initial Poor Compensation of Type 2 Diabetes Mellitus in Correction of Hypertension with Angiotensin II Receptor Antagonists during a year

N.O. Pertseva


The purpose of this study is to determine the dynamics of endothelial dysfunction intensity in patients with poor compensation of type 2 diabetes mellitus and hypertension treating with angiotensin II receptor antagonists during a year. It was shown that adequate hypoglycemic standard treatment allowed reduce the concentration of glycated hemoglobin level below 8 % in 48.6 % of patients and cause regression of microalbuminuria in 18.6 % of patients, but most patients had progressive endothelial dysfunction with increased concentrations of endothelin 1 and von Willebrand factor on 38.3 % (p < 0.05) and 27.8 % (p < 0.05), respectively versus baseline values, which was many times larger than control values. Hypoglycemic therapy in patients treated with angiotensin II receptor antagonists provided a reduction of glycated hemoglobin level to 7–8 % in 46.5 % of patients, and its normalization in 7.0 % of patients, followed by regression of microalbuminuria in 23.3 % of patients.


type 2 diabetes mellitus; hypertension; endothelial dysfunction


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DOI: https://doi.org/10.22141/2224-0721.7.63.2014.77119


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