The Role of Glycated Hemoglobin in the Diagnosis and Monitoring of Diabetes Mellitus

Main Article Content

L.А. Lutsenko


Considering the prevalence of diabetes mellitus, the possibility of early and rapid progress of complications, a large number of undiagnosed cases and disappointing forecasts of the WHO on the prospects of diabetes mellitus spreading in the world, timely and accurate diagnosis of carbohydrate metabolism disorders is important. The glycated hemoglobin — an indicator that, while using the standardized methods, provides an integrated view of the glycemia level during a long period of time and allows timely detection of carbohydrate metabolism disorders. When using the glycated hemoglobin as a diagnostic criterion for detecting carbohydrate metabolism disorders or degree of diabetes mellitus compensation, the correct approach to the choice of the method of this index determination, considering its analytical reliability, is important.

Article Details

How to Cite
Lutsenko, L. “The Role of Glycated Hemoglobin in the Diagnosis and Monitoring of Diabetes Mellitus”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 6.62, Oct. 2014, pp. 130-4, doi:10.22141/2224-0721.6.62.2014.76947.
To practicing Endocrinologists


International Diabetes Federation, Diabetes Atlas. — 6th edition. — 2013. — 159 р.

Gonen B.A. Hemoglobin A1: An indicator of the metabolic control of diabetic patients / B.A. Gonen, A.H. Rubinstein, H. Rochman et al. // The Lancet. — 1977. — Vol. 310. — Р. 734-737.

Koenig R.J. Correlation of glucose regulation and hemoglobin A1c in diabetes mellitus / R.J. Koenig, C.M. Peterson, R.L. Jones et al. // New England Journal of Medicine. — 1976. — Vol. 295, № 8. — P. 417-420.

Korolev V. A. Metod yzoyelektrofokusyrovanyya y fotokolorymetryya dlya opredelenyya hemohlobyna A1s / V. A. Korolev, V. Y. Molchanov // Byomedytsynskaya khymyya. — 2006. — T.52, №2. — P. 200-210.

Pyters-Kharmel Ye. Sakharnyy dyabet: dyahnostyka y lechenye / Ye. Pyters-Kharmel, R. Matur. Per. s anhl. — M.: Praktyka, 2008. — 496 p.

American Diabetes Association Standards of Medical Care in Diabetes — 2010 // Diabetes Care. — 2010. — Vol. 33 (1). — P. 511-561.

International expert committee report on the role of the A1c assay in the diagnosis of diabetes // Diabetes Care. — 2009. — Vol. 32 (7). — P. 1327-1334.

Approved IFCC reference method for the measurement of HbA1c in human blood // Clin. Chem. Lab. Med. — 2002. — Vol. 40 (1). — Р. 78-89.

DCCT. The relationship of glycemic exposure (HbA1c) to the risk of development and progression of retinopathy in the diabetes control and complications trial // Diabetes. — 1995. — Vol. 44 (8). — P. 968-983.

Stratton J.M. Association of glycaemia with macrovascular and microvascular complications of type 2 diabetes (UKPDS 35): prospective, observational study / J.M. Stratton, A.I. Adler, A.W. Neil et al. // BMJ. — 2000. — Vol. 321. — Р. 405-412.

Hnudy L. Rezul'taty y vlyyanye yssledovanyy ACCORD y ADVANCE / L. Hnudy // Diabetes voice. — 2009. — Vol. 54, №1. — P. 29-32.