Peculiarities of Changes in Daily Blood Pressure and Its Variability in Patients with Essential Hypertension and Diabetes Mellitus Type 2

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E.Yu. Gura


The aim of the study was to determine the peculiarities of changes in daily blood pressure (BP) and its variability in patients with essential hypertension (EH) and diabetes mellitus type 2 (DM type 2).
150 patients of average age 53.4 ± 5.3 years old were examined. Patients were divided into groups: 30 healthy persons, 30 patients with DM type 2, 30 patients with EH and 60 patients with EH combined with DM type 2.
Daily BP monitoring (DBPM) was performed using the apparatus ABPM-04. The patients with DM type 2 compared to healthy persons were found to have significantly increased (p < 0.05) daily, daytime and night diastolic BP (DBPdaily, DBPnight, DBPday). Time indexes of night systolic blood pressure (SBPnight) and daytime systolic blood pressure (SBPday) were elevated by 2.01 and 1.80 times.
There was significantly increased rate pressure product (RPP) that was a marker of a high level of load with high blood pressure in those patients.
In patients with essential hypertension combined with diabetes mellitus type 2 associated with II stage hypertension in comparison with a group with essential hypertension, the parameters of DBPM did not much differ, and the indices of SBPdaily, SBPday, SBPnight, were significantly (p < 0.02) reduced, and the rate of DP was significantly (p < 0.05) higher versus the group of comparison. In patients with III stage hypertension the parameters of night blood pressure decrease (SBP, DBP) were significantly higher. There were significantly (p < 0.05) elevated the DP values, daily and night blood pressure, that was a marker of unfavorable hemodynamic parameters during the day and especially at night.
In patients with essential hypertension combined with diabetes type 2 dipper and non-dipper circadian rhythms prevailed. They had higher values of SBP variability in the daytime, load with high blood pressure in the daytime and at night; the degree of the insufficient night reduction and morning increase of BP. Those parameters were significantly in non-dipper circadian rhythm.

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How to Cite
Gura, E. “Peculiarities of Changes in Daily Blood Pressure and Its Variability in Patients With Essential Hypertension and Diabetes Mellitus Type 2”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 6.62, Oct. 2014, pp. 109-16, doi:10.22141/2224-0721.6.62.2014.76944.
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Каминский А.В. Сахарный диабет: новые взгляды и старые заблуждения. Современные представления о патогенезе и патогенетической терапии СД 2-го типа // Міжнародний ендокринологічний журнал. — 2012. — № 6. — С. 50-53.

Коваленко В.М., Сіренко Ю.М., Дорогой А.П. Реалізація Програми профілактики і лікування артеріальної гіпертензії в Україні // Український кардіологічний журнал. — 2010. — Додаток 1. — С. 3-12.

Сіренко Ю.М. Цільовий рівень артеріального тиску при цукровому діабеті 2-го типу: оцінка наукових доказів // Міжнародний ендокринологічний журнал. — 2012. — № 6. — С. 10-14.

Сіренко Ю.М. Артеріальна гіпертензія. — К.: Моріон, 2001. — 176 с.

Sierra C., De la Sierra A., Sobrino J. et al. en representacion de los Investigadores del Registro Nacional de MAPA; Sociedad Espanola de Hipertension-Liga Espanola para la Lucha contra la Hipertension Arterial (SEH-LELHA): Ambulatory blood pressure monitoring (CABPM): clinical characteristics of 31,530 patients // Med. Clin. (Barc). — 2007. — 129. — Р. 1-5.

Guasti L., Simoni C., Mainardi L.T. et al. Circadian blood pressure variability is associated with autonomic and baroreflex-mediated modulation of the sinoatrial node // Acta Cardiol. — 2005. — Vol. 60 (3). — P. 319-324.

Asayama K., Ohkubo T., Kikuya M., Obara T., Metoki H., Inoue R. et al. Prediction of stroke by home ‘morning’ versus ‘evening’ blood pressure values: the Ohasama study // Hypertension. — 2006. — Vol. 48 (4). — P. 737-743.

Waeber B., Heynen G., Brunner H.R. Analysis of ambulatory blood pressure monitoring: the problem of white coаt hypertension, responders and non responders // Blood Pressure Monit. — 1996. — Vol. 1. — P. 289-291.