Experience of Using Pentosan Polysulfate SP 54 in Patients with Diabetic Foot Syndrome

Main Article Content

I.V. Nosenko

Abstract

Diabetic foot — a complex of anatomical and functional changes in the feet caused by diabetic neuropathy leading to osteoarthropathy and angiopathy, against which purulent necrotic processes may develop. Microangiopathy determines basement membrane thickening with deposition in it of PAS-positive substances, endothelial proliferation, leading to circulatory disturbances and, consequently, to the development of thrombosis, embolism, prolonged vasoconstriction. In the treatment for diabetic foot syndrome, heparinoids took leading positions. Application of such heparinoid, as Pentosan polysulfate SP 54, is promising. Its multivector (anticoagulant, fibrinolytic and lipid-lowering) effect on the factor Xa, regardless of antithrombin III, makes it possible to carry out the treatment for diabetic foot syndrome.

Article Details

How to Cite
Nosenko, I. “Experience of Using Pentosan Polysulfate SP 54 in Patients With Diabetic Foot Syndrome”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 6.62, Oct. 2014, pp. 78-82, doi:10.22141/2224-0721.6.62.2014.76940.
Section
To practicing Endocrinologists
Author Biography

I.V. Nosenko, State Institution «Railway Clinical Hospital of Dnipropetrovsk Station of State Enterprise «Dnieper Railway»

Department of Purulent-Septic Surgery