State of Left Ventricular Systolic and Diastolic Function in Patients with Postinfarction Cardiosclerosis and Obesity

P.P. Kravchun

Abstract


Cardiovascular diseases are one of the major causes of mortality worldwide, the main contribution to its structure belongs to ischemic heart disease. One of the major factors for the progression of ischemic heart disease is obesity.
The objective of the work — to carry out an analysis of the state of left ventricular systolic and diastolic function in patients with postinfarction cardiosclerosis and obesity.
Materials and Methods. The study retrospectively included 76 patients with ischemic heart disease, who had myocardial infarction, with concomitant obesity. Comparison group consisted of 80 patients with ischemic heart disease, who had myocardial infarction, without obesity. All patients underwent general clinical and instrumental examination. Statistical analysis of the data was performed using the statistical software package Statistica 8.0, Microsoft Office Excel 2003.
Results. It is found that the degree of reduction in left ventricular contractility is an important indicator of myocardial compensatory reserves exhaustion and has a significant impact on the severity of clinical manifestations in patients with postinfarction cardiosclerosis and obesity.
Conclusions. Comorbidity of obesity and postinfarction remodeling potentiate the increase of the heart size, dilatation of the heart cavities on the background of inotropic myocardial function reduction. In most patients with postinfarction cardiosclerosis and obesity, left ventricular diastolic dysfunction manifested by a type of relaxation disturbance.


Keywords


postinfarction cardiosclerosis; obesity; systolic function; diastolic function

References


Netyazhenko VZ, Bydzylya PP Strukturnye yzmenenyya myokarda pry khronycheskoy serdechnoy nedostatochnosty II funktsyonal'noho klassa na fone yzbytochnoy massy tela y abdomynal'noho ozhyrenyya. Zaporozhskyy medytsynskyy zhurnal 2014;2 (83):22–25.

Avelar E, Cloward TV, Walker JM, Farney RJ, Strong M, Pendleton RC, Segerson N, Adams TD, Gress RE, Hunt SC, Litwin SE. Left ventricular hypertrophy in severe obesity: interactions among blood pressure, nocturnal hypoxemia, and body mass. Hypertension. 2007;49:34 –39. doi: 10.1161/01.HYP.0000251711.92482.14.

Di Bello V, Fabiani I, Conte L, Barletta V, Grazia Delle Donne M, Cuono C, Leo LA, Dini FL, Marzilli M, Pinchera A, Santini F New echocardiographic techniques in the evaluation of left ventricular function in obesity. Obesity 2013;21(5):881–892. DOI: 10.1002/oby.20071.

Elliott WJ, Meier PM Incident diabetes in clinical trials of antihypertensive drugs: a network meta-analysis. [erratum in Lancet 369:1518, 2007] Lancet 2007;369:201.

Frankel DS, Vasan RS, D’Agostino RB, Sr, et al. Resistin, adiponectin, and risk of heart failure the Framingham offspring study. J Am Coll Cardiol. 2009;53:754–762. doi: 10.1016/j.ahj.2011.09.029.

Iacobellis G, Leonetti F. Epicardial adipose tissue and insulin resistance in obese subjects. J Clin Endocrinol Metab 2005; 90 (11): 6300–6302. http://dx.doi.org/10.1210/jc.2005-1087.

Kosmala W, Wong C, Kuliczkowska J, Leano R, Przewlocka-Kosmala M, Marwick TH. Use of body weight and insulin resistance to select obese patients for echocardiographic assessment of subclinical left ventricular dysfunction. Am J Cardiol 2008; 101: 1334–1340. doi: 10.1016/j.amjcard.2007.12.034.

Lloyd-Jones D., Adams R. J., Brown T. M. et al. Heart disease and stroke statistics – 2010 update: A report from the American Heart Association. Circulation 2010;121:e46. doi: 10.1161/CIRCULATIONAHA.109.192667. Epub 2009 Dec 17.

Poirier P, Giles TD, Bray GA, Hong Y, Stern JS, Pi-Sunyer FX, Eckel RH. Obesity and Cardiovascular Disease Pathophysiology, Evaluation, and Effect of Weight Loss. Arterioscler. Thromb. Vasc. Biol. 2006; 26:968–976.

Roger V. L., Go A. S., Lloyd-Jones D. M. et al. AHA Statistical Update. Heart Disease and Stroke Statistics – 2012 Update. A Report From the American Heart Association. Circulation 2012;125:e2–e220. doi: 10.1161/CIR.0b013e31823ac046.

Varas-Lorenzo C., Margulis A. V., Pladevall M. et al. The risk of heart failure associated with the use of noninsulin blood glucose-lowering drugs: systematic review and meta-analysis of published observational studies. BMC Cardiovasc Disord 2014;Sep 26;14(1):129.

Thygesen K., Alpert J. S., Jaffe A. S. et al. Third universal definition of myocardial infarction [Text]. Circulation 2012;126:2020–2035. doi: 10.1161/CIR.0b013e31826e1058.

Tribouilloy C., Rusinaru D., Mahjoub H. et al. Prognosis of heart failure with preserved ejection fraction: a 5 year prospective population-based study. European Heart Journal 2008;29:339–347.

Wang T.J., Parise H., Levy D., Sr D’Agostino R.B., Wolf P.A. et al. Obesity and the risk of new-onset atrial fi brillation. J. Am. Med. Assoc. 2004;292:2471–2477.




DOI: https://doi.org/10.22141/2224-0721.6.62.2014.76934

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