Impact of Physical Activity on Dyslipidemia Onset in Children and Adolescents with Type 1 Diabetes Mellitus

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O.A. Budreiko
O.V. Morozov


The problem of treatment optimization for type 1 diabetes mellitus (DM) in children is not completely resolved so far, while recommendations concerning physical activity (PA) regimen usually do not consider the features of patients’ metabolic status. Objective of this article — to determine the features of blood lipid depending on PA level of children and adolescents with DM type 1. Materials and Methods. The study involved 173patients with DM type 1 aged 7–18 years, with disease duration from 1 to 10 years, with determination of carbohydrate metabolism indicators, blood lipids, as well as FA level using a modified adapted questionnaire. Results. It was found that children and adolescents with type 1 DM reported atherogenically directed lipid changes in terms of increased levels of total cholesterol, low-density lipoprotein (LDL) cholesterol, low-density lipoprotein (VLDL) cholesterol and triglycerides (TG) combined with a decreased level of high-density lipoprotein (HDL) cholesterol. Identified lipid disorders were to a large degree associated with decompensation of the disease. High PA levels in children with type 1 DM is accompanied by various lipid changes depending on the state of metabolic compensation — at HbA1c level < 9 % we observed increased indicators of TG, LDL cholesterol and VLDL cholesterol, while at HbA1c level > 7.5 % — decreased HDL cholesterol. The findings show a different impact of high PA level on the state of metabolism in children with DM type 1, in particular the possibility of dyslipidemia onset and increased risk of diabetic complications.

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How to Cite
Budreiko, O., and O. Morozov. “Impact of Physical Activity on Dyslipidemia Onset in Children and Adolescents With Type 1 Diabetes Mellitus”. INTERNATIONAL JOURNAL OF ENDOCRINOLOGY (Ukraine), no. 6.62, Oct. 2014, pp. 33-36, doi:10.22141/2224-0721.6.62.2014.76933.
Original Researches


Болотова Н.В. Нарушения метаболизма у детей с сахарным диабетом 1-го типа и их коррекция / Болотова Н.В., Скучаева Л.В., Новикова Е.П., Николаева Н.В. [Електронний ресурс] // Лечащий врач. — 2010. — № 4. —

Сенаторова Г.С. Предиктори серцево-судинних ускладнень у дітей із цукровим діабетом I типу [Електронний ресурс] // Здоровье ребенка. — 2009. — № 4(19). —

Blessing D.L. Blood lipid and physiological responses to endurance training in adolescents [Text] / D.L. Blessing, R.E. Keith, H.N. Williford et al. // Ped. Exerc. Sci. — 1995. — Vol. 7. — P. 192-202.

Белая Ж.Е. Роль физических нагрузок в норме и при сахарном диабете [Текст] / Ж.Е. Белая, О.М. Смирнова, И.И. Дедов // Пробл. эндокринологии. — 2005. — № 2. — С. 28-37.

Rigla M. Effect of physical exercise on lipoprotein a LDL-c modifications in type 1 & 2 diabetic patients [Text] / M. Rigla, J.L. Sanchez-Quesada, J. Ordóñez-Llanos et al. // Metabolism. — 2000. — Vol. 49, № 5. — Р. 640-647.

Schmitz K.H. Association of physical activity with insulin sensitivity in children [Text] / K.H. Schmitz, D.R. Jacobs Jr., C.P. Hong et al. // Int. J. Obes. Relat. Metab. Disord. — 2002. — Vol. 26. — Р. 1310-1316.

Kelley G.A. Aerobic exercise and lipids and lipoproteins in children and adolescents: A meta-analysis of randomized controlled trials [Text] / G.A. Kelley, K.S. Kelley // Atherosclerosis. — 2007. — Vol. 191. — P. 447-453.

Koozehchian M.S. The role of exercise training on lipoprotein profiles in adolescent males [Електронний ресурс] / M.S. Koozehchian, F. Nazem, R.B. Kreider et al. // Lipids in Health and Disease. — 2014. — 13. — 95. —

Морозов О.В. Оцінка фізичної активності у здорових та хворих на цукровий діабет дітей і підлітків (огляд літератури та власні дані) / О.В. Морозов, О.А. Будрейко // Проблеми ендокринної патології. — 2013. — № 4. — С. 78-87.

ISPAD Clinical Practice Consensus Guidelines 2009 Compendium // Pediatric Diabetes. — 2009. — Vol. 10 (Suppl. 12). — 210 p.