Apelin Role in the Development of Glucose Metabolism Disorders (Review of the Literature and Our Own Researches)

G.V. Demidenko


The physiological and pathogenetic role of adipokine apelin, endogenous ligand of apelin (APJ or APLNR) receptors in the development of glucose metabolism disorders has been analyzed. Established correlations of apelin with components of carbohydrate metabolism confirm the effect on glucose metabolism manifestations. Ambiguous data about apelin level at insulin resistance syndrome, prediabetes, diabetes mellitus type 2, hypertension require further detailed study. The close association of apelin with development of diabetes mellitus type 2 and prediction of cardiovascular events in patients with metabolic syndrome has been found.


obesity; adipokines; apelin; cardiometabolic risk


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