The Role of Visceral Adipose Tissue in the Development of Hormonal and Metabolic Disorders in Patients with Diabetes Mellitus Type 2, Obesity and Arterial Hypertension

K.O. Zuyev


The article presents the results of adipokines (leptin and adiponectin) level study, as well as insulin resistance and secretory activity of the β-cells of the pancreas, depending on the amount of adipose tissue and its distribution type, studied using dual-energy X-ray absorptiometry, in 106 patients (50 men and 56 women aged 55.90 ± 2.15 years) with diabetes mellitus (DM, type 2, obesity and arterial hypertension, as compared with the control group (without DM, obesity, and hypertension). It has been shown that an excess amount of adipose tissue in patients with DM type 2 affects the development of hormone-metabolic disorders related to the features of adipokines production. It was found that overproduction of leptin by adipose tissue and decreased basal level of adiponectin in obesity create conditions to decrease the sensitivity of target cells to insulin-mediated glucose uptake, defatigation and subsequent depletion of the secretory function of β-cells of the pancreas, as well as to the maintenance of steady state of resistance to insulin and glucose homeostasis deviation towards hyperglycemic conditions prevail. Also there been shown physiologically determined sexual dimorphism of adipokines level conditioning higher tolerance of the female body to excess of adipose tissue mass. It was confirmed that the state of hyperleptinemia and hypoadiponectinemia underlie disorders of carbohydrate metabolism in patients with DM 2 with obesity and hypertension.


diabetes mellitus type 2; obesity; arterial hypertension; leptin; adiponectin; dual-energy X-ray absorptiometry; adipose tissue


Kershaw E.E., Flier J.S. Adipose tissue as an endocrine organ // J. Clin. Endocrinol. Metab. — 2004. — Vol. 89, № 6. — P. 2548-2556.

Ahima R.S., Qi Y., Singhal N.S. et al. Brain adipocytokine action and metabolic regulation // Diabetes. — 2006. — Vol. 55, Suppl. 2. — P. 145-154.

Tschritter O., Fritsche A., Thamer C. et al. Plasma adiponectin concentrations predict insulin sensitivity of both glucose and lipid metabolism // Diabetes. — 2003. — Vol. 52. — P. 239-243.

Kadowaki T., Yamauchi T., Kubota N. et al. Adiponectin and adiponectin receptors in insulin resistance, diabetes, and the metabolic syndrome // J. Clin. Invest. — 2006. — 116(7). — 1784-1792.

Widjaja A., Stratton I.M., Horn R. et al. UKPDS 20: plasma leptin, obesity, and plasma insulin in type 2 diabetic subjects // J. Clin. Endocrinol. Metab. — 1997. — Vol. 82. — P. 654-657.

Рекомендації Української асоціації кардіологів з профілактики та лікування артеріальної гіпертензії. Посібник до Національної програми профілактики і лікування артеріальної гіпертензії. — К.: ПП ВМБ, 2008. — 80 с.

Wallace T.M., Levy J.C., Matthews D.R. Use and abuse of HOMA modeling // Diabetes Care. — 2004. — Vol. 27, № 6. — P. 1487-1495.

Freedman D.A. Statistical Models: Theory and Practice. — Cambridge University Press, 2005. — 414 p.

Saad M.F., Damani S., Gingerich R.L., Riad-Gabrial M.G. et al. Sexual dimorphism in plasma leptin concentration // J. Clin. Endocrinol. Metab. — 1997. — Vol. 82. — P. 579-584.

Böttner A., Kratzsch J., Müller G. et al. Gender differences of adiponectin levels develop during the progression of puberty and are related to serum androgen levels // J. Clin. Endocrinol. Metab. — 2004. — Vol. 89, № 8. — P. 4053-4061.

Танянский Д.А., Фирова Э.М., Шатилина Л.В., Денисенко А.Д. Роль адипокинов и неэстерифицированных жирных кислот в развитии инсулинорезистентности // Проблемы эндокринологии. — 2009. — Т. 55, № 3. — С. 13-17.

Haluzik M., Parizkova J., Haluzik M.M. Adiponectin and its role in the obesity-induced insulin resistance and related complications // Physiol. Res. — 2004. — Vol. 53. — P. 123-129.

Ukkola O., Santaniemi M. Adiponectin: a link between excess adiposity and associated comorbidities? // J. Mol. Med. — 2002. — Vol. 80. — P. 696-702.

Триголосова И.В. Нарушения продукции глюкозы печенью и лептина в патогенезе сахарного диабета 2 типа: Дис... канд. мед. наук. — М., 2010. — 93 с.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2018


   Seo анализ сайта