Influence of Hypothyroidism on Separate Links of Metabolism, Structure and Function of the Heart in Insulin Resistance

T.Yu. Yuzvenko


The article presents research findings of reduced thyroid function impact on the background of insulin resistance on the specific links of metabolism, structure and function of the heart. It is found that in thyroid dysfunction, the main nosological form of myocardial lesion in female patients without concomitant cardiovascular disease is the development of metabolic endocrine cardiomyopathy. Feature of cardiac lesion is the absence of cardiosclerotic, myocardial and ischemic processes in hypothyroidism. Obscure clinical symptoms of the heart both in apparent and subclinical hypothyroidism are detected. Features of clinical, instrumental and laboratory changes in female patients with impaired thyroid function are a trend to systolic blood pressure increase, the absence of significant dyslipidemia, dysglycemia, and cardiocytolysis and hepatocytolysis. Thyroid hormone deficiency is associated with increased myocardial repolarization heterogeneity: subclinical hypothyroidism is accompanied by violation of repolarization processes and the development of electrical heterogeneity of ventricular myocardium, and in the apparent hypothyroidism changes are more linked with the violation of the homogeneity of the electrical impulse to the atria.


hypothyroidism; insuline resistance; myocardial function


Балаболкин М.И., Клебанова Е.М., Креминская В.М. Фундаментальная и клиническая тиреоидология: Руководство. — М.: Медицина, 2007. — 816 с.

Карась А.С. Щитовидная железа и сердце / Карась А.С., Обрезан А.Г. // Клиническая и экспериментальная тиреоидология. — 2009. — № 3. — С. 37-42.

Brenta G. Diabetes and thyroid disorders // British Journal of Diabetes and Vascular Disease. — 2010. — Vol. 10(4). — P. 172-177.

Cappola A.R., Fried L.P., Arnold A.M. et al. Thyroid status, cardiovascular risk, and mortality in older adults // JAMA. — 2006 — Vol. 295, № 9. — P. 1033-1041.

Flynn R.W., McDonald T.M., Jung R.T. et al. Mortality and vascular outcomes in patients treated for thyroid dysfunction // J. Clin. Endocrinol. Metab. — 2006. — Vol. 91, № 6. — P. 2159-2164.

Kahn R., Buse J., Ferrannini E., Stern M.; American Diabetes Association; European Association for the Study of Diabetes. The metabolic syndrome: time for a critical appraisal: joint statement from the American Diabetes Association and the European Association for the Study of Diabetes // Diabetes Care. — 2005. — Vol. 28(9). — P. 2289-2304.

Rodondi N., Aujesky D., Vittinghoff E. et al. Subclinical hypothyroidism and the risk of coronary heart disease: a meta-analysis // Am. J. Med. — 2006. — Vol. 119, № 7. — P. 541-551.

Creative Commons License
This work is licensed under a Creative Commons Attribution 4.0 International License.


© "Publishing House "Zaslavsky", 1997-2018


   Seo анализ сайта