The Content of Insulin-Like Growth Factor 1 and Essential Trace Elements in the Blood Plasma of Children with Different Forms of Short Stature
The content of insulin-like growth factor 1 and essential trace elements (zinc, selenium, copper, manganese, chromium) was studied in the blood plasma of children with short stature, depending on the etiology of the disease. The presence of a significant imbalance of essential trace elements in patients with short stature, primarily caused by deficiency of growth hormone and insulin-like growth factor 1, was established. The significant weak correlation between indicators of insulin-like growth factor 1 and the average level of zinc in the blood plasma of children with short stature was noted in the whole group. At the same time, the significant strong correlation between indicators of insulin-like growth factor‑1 and zinc in the blood plasma was revealed in children with isolated growth hormone deficiency, full or partial. No correlation was found between indices of insulin-like growth factor 1 in the blood plasma and indices of selenium, manganese, chromium, copper.
Bolshova OV, Pahomova VG. Zinc and his value are for a height and sexual development of children. Clinical Endocrinology and Endocrine Surgery. 2011;3 (36): 77-82.
Bolshova OV, Pahomova VG, Sprinchuk NA. Content of zinc in the organism of children and teenagers with somatotropic insufficiency // Likarska Sprava. 2013;5:70-75.
Goncharova NN. Physical development and functional state of children of midchildhood with a different somatic health level. Pedagogika, psihologiya i mediko-biologicheskie problemyi fizicheskogo vospitaniya i sporta. 2007;5:57-59.
Netrebenko OK. Some essencial micronutrients in the feed of prematurely born children. – М., 2004; 5-83.
Ahn J. Effects of zinc and essential acids deficiency on the lymphatic adsorption of vitamin A and secretion of phospholipids. J. Nutr. Bioch. 1995;6:595-603.
Ohlsson C, Bengtsson BA, Isaksson OG. Growth hormone and bone. Endocrin. Rev. 1998;19:55-79.
Rains TM., Mangian H.F., Liang T. Growth hormone–releasing factor affects macronutrient intake during the anabolic phase of zinc repletion: total hypothalamic growth hormone-releasing factor content and growth hormone-releasing factor immunoneutralization during zinc repletion. J. Nutritional Neuroscience. 2001;.4(4): 282-294.
Gude D. Tracing elements’ in hair. Int. J. Trichology. 2011; 3(2):132-133.
Ozmen H, Akarsu S, Polat F, Cukurovali A. The levels of calcium and magnesium, and of selected trace elements, in whole blood and scalp hair of children with growth retardation. Iran J. Pediatr. 2013;23(2):125-130.
Imdad A, Bhutta ZA. Effect of preventive zinc supplementation on linear growth in children under 5 years of age in developing countries: a meta-analysis of studies for input to the lives saved tool. BMC Public Health. 2011;11(3):22.
MacDonald R. The role of zinc in growth and cell proliferation. J. Nutr. 2000;130:1500-1508.
Mayo-Wilson E. Zinc supplementation for preventing mortality, morbidity, and growth failure in children aged 6 months to 12 years of age. Cochrane Database of Systematic Reviews. 2014;5: Art. No.: CD009384.
Ren SC. Direct administration of testosterone increases rat tibial epiphyseal growth plate width. Acta Endocrinol. 1989;121:401-404.
World Health Organization. Trace elements in human nutrition. Geneva: WHO. 1992.
This work is licensed under a Creative Commons Attribution 4.0 International License.
© "Publishing House "Zaslavsky", 1997-2018